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AB252200

CD163 Antibody Panel (EPR14643-36, EPR19518, EPR14643)

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(2 Publications)

CD163 Antibody Panel (EPR14643-36, EPR19518, EPR14643) (ab252200) is part of our antibody panels range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.
3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD163 Antibody Panel (EPR14643-36, EPR19518, EPR14643) (AB252200)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD163 Antibody Panel (EPR14643-36, EPR19518, EPR14643) (AB252200)

Immunohistochemical analysis of paraffin-embedded Human stomach tissue labeling CD163 with ab188571 at 1/500 with prediluted ImmunoHistoprobe(Ready to use) HRP Polymer for Rabbit IgG as secondary antibody.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD163 Antibody Panel (EPR14643-36, EPR19518, EPR14643) (AB252200)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD163 Antibody Panel (EPR14643-36, EPR19518, EPR14643) (AB252200)

Immunohistochemical analysis of paraffin embedded Human liver tissue labeling CD163 with ab189915 at 1/1000 with prediluted ImmunoHistoprobe(Ready to use) HRP Polymer for Rabbit IgG as secondary antibody.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD163 Antibody Panel (EPR14643-36, EPR19518, EPR14643) (AB252200)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD163 Antibody Panel (EPR14643-36, EPR19518, EPR14643) (AB252200)

Immunohistochemical analysis of paraffin-embedded mouse spleen tissue labeling CD163 with ab182422 at 1/500 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/500 dilution. Cytoplasm staining on mouse spleen is observed. Counter stained with Hematoxylin. Secondary antibody only control : Used PBS instead of primary antibody, secondary antibody is ab97051 at 1/500 dilution.

Key facts

Reacts with

Human

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Secondary Antibodies

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Product details

CD163 Antibody Panel ab252200 contains multiple trial-sized versions of anti-human antibody clones against CD163, specifically selected for high performance in IHC. This panel contains 3 recombinant rabbit monoclonal antibodies against human CD163. They are provided in trial sizes to allow you to easily evaluate which is the best CD163 antibody for your IHC research assay needs.

For guidelines on how to use each antibody within the panel, please consult the individual datasheet for each antibody.

Panel contains:

- Rabbit monoclonal [EPR14643] to CD163 - C-terminal (20 μL) ab188571

- Rabbit monoclonal [EPR14643-36] to CD163 - C-terminal (20 μL) ab189915

- Rabbit monoclonal [EPR19518] to CD163 (20 μL) ab182422

Explore our range of antibody sample panels designed to provide you with a variety of trial-size antibodies in a convenient and cost-effective format.

Carrier-free formulations of our recombinant antibodies are also available for easy conjugation to labels of your choice and for multiplex applications. Use our intuitive search and select carrier-free or your label of choice. For bespoke conjugations or large volumes email bespoke@abcam.com.

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What's included?

{ "values": { "1Kit": { "sellingSize": "1 Kit", "publicAssetCode":"ab252200-1Kit", "assetComponentDetails": [ { "size":"2 x 10 µL", "name":"Anti-CD163 antibody [EPR19518]", "number":"AB252200-CMP01", "productcode":"AB182422" }, { "size":"2 x 10 µL", "name":"Anti-CD163 antibody [EPR14643] - C-terminal", "number":"AB252200-CMP03", "productcode":"AB188571" }, { "size":"2 x 10 µL", "name":"Anti-CD163 antibody [EPR14643-36] - C-terminal", "number":"AB252200-CMP02", "productcode":"AB189915" } ] } } }
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD163 known also as hemoglobin scavenger receptor is a membrane glycoprotein with a molecular weight of approximately 130 kDa. It is predominantly expressed by monocytes and macrophages which are types of immune cells. Located on the cell surface CD163 functions as a receptor that aids in the clearance of hemoglobin-haptoglobin complexes playing a critical role in maintaining iron homeostasis and protecting tissues from oxidative damage. CD163 is not limited to human cells only; researchers often study its function using animal models such as chimeric rodents and chimeric rats.
Biological function summary

CD163 participates in anti-inflammatory processes and is linked to immune modulation. It plays a pivotal role in the resolution of inflammation and promotes the removal of damaged cells and tissues. Through its involvement in the endocytic pathway CD163 interacts with various ligands facilitating interactions with other proteins. In the context of research CD163 functionality can be analyzed using techniques like CD163 IHC CD163 ELISA and CD163 stain in both human and mouse models.

Pathways

CD163 is integral to the inflammation and immune response pathways. It participates in the heme-oxygenase pathway which is essential in the breakdown of heme into biliverdin free iron and carbon monoxide. This pathway involvement is tightly linked with heme oxygenase-1 (HO-1) a cytoprotective enzyme that helps to mitigate inflammatory responses. The interaction with haptoglobin and related proteins provides further insight into its regulatory roles within the immune system.

CD163 is associated with conditions like atherosclerosis and acute inflammation disorders. Its elevated levels indicate macrophage activation observed in chronic inflammations such as cardiovascular diseases. In atherosclerosis CD163 expression correlates with the uptake of oxidized LDL connecting it to progression of the disease. Additionally soluble CD163 levels serve as a biomarker in conditions like chronic liver disease where it is linked to macrophage activation and fibrosis. Within these disorders proteins like LDL and inflammatory cytokines are closely associated with CD163 function and regulation.
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Product protocols

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Target data

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of biochemical and molecular toxicology 36:e23115 PubMed35822655

2022

Cdc42 promotes thyroid cancer cell proliferation and migration and tumor-associated macrophage polarization through the PTEN/AKT pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Deyi Huang,Huali Qiu,Lin Miao,Lin Guo,Xiaoting Zhang,Mengmeng Lin,Zhongyun Li,Fang Li

Journal for immunotherapy of cancer 9: PubMed33579737

2021

CMTM6 and PD-L1 coexpression is associated with an active immune microenvironment and a favorable prognosis in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Qi-Hua Peng,Chun-Hua Wang,Hong-Min Chen,Rong-Xin Zhang,Zhi-Zhong Pan,Zhen-Hai Lu,Gao-Yuan Wang,Xin Yue,Wenlin Huang,Ran-Yi Liu
View all publications
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Product promise

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