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AB252195

GITR Antibody Panel (EPR20566, CAL8, CAL52)

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(1 Publication)

GITR Antibody Panel (EPR20566, CAL8, CAL52) (ab252195) is part of the multiplex kits range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.
3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GITR Antibody Panel (EPR20566, CAL8, CAL52) (AB252195)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GITR Antibody Panel (EPR20566, CAL8, CAL52) (AB252195)

Formalin-fixed, paraffin-embedded human tonsil tissue stained for GITR using ab237713 at 0.25 μg/ml in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GITR Antibody Panel (EPR20566, CAL8, CAL52) (AB252195)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GITR Antibody Panel (EPR20566, CAL8, CAL52) (AB252195)

Immunohistochemical analysis of paraffin-embedded human Hodgkin's lymphoma tissue labeling GITR with ab223841 at 1/1000 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) Ready to use. Cytoplasmic staining in sporadic cells (arrows) in human Hodgkin's lymphoma (PMID : 25787078; PMID : 23785514). Counter stained with hematoxylin.

Secondary antibody only control : Used PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GITR Antibody Panel (EPR20566, CAL8, CAL52) (AB252195)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GITR Antibody Panel (EPR20566, CAL8, CAL52) (AB252195)

Formalin-fixed, paraffin-embedded human tonsil tissue stained for GITR using ab237714 at 0.5 μg/ml in immunohistochemical analysis.

Key facts

Reacts with

Human

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Product details

GITR Antibody Panel ab252195 contains multiple trial-sized versions of anti-human antibody clones against GITR, specifically selected for high performance in IHC. This panel contains 3 recombinant rabbit monoclonal antibodies against human GITR. They are provided in trial sizes to allow you to easily evaluate which is the best GITR antibody for your IHC research assay needs.

For guidelines on how to use each antibody within the panel, please consult the individual datasheet for each antibody.

Panel contains:

- Rabbit monoclonal [CAL52] to GITR (20 μL) ab237713

- Rabbit monoclonal [CAL8] to GITR (20 μL) ab237714

- Rabbit monoclonal [EPR20566] to GITR (20 μL) ab223841

Explore our range of antibody sample panels designed to provide you with a variety of trial-size antibodies in a convenient and cost-effective format.

Carrier-free formulations of our recombinant antibodies are also available for easy conjugation to labels of your choice and for multiplex applications. Use our intuitive search and select carrier-free or your label of choice. For bespoke conjugations or large volumes email bespoke@abcam.com.

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What's included?

{ "values": { "1Kit": { "sellingSize": "1 Kit", "publicAssetCode":"ab252195-1Kit", "assetComponentDetails": [ { "size":"2 x 10 µL", "name":"Anti-GITR antibody [EPR20566]", "number":"AB252195-CMP01", "productcode":"AB223841" }, { "size":"2 x 10 µL", "name":"Anti-GITR antibody [CAL8]", "number":"AB252195-CMP03", "productcode":"AB237714" }, { "size":"2 x 10 µL", "name":"Anti-GITR antibody [CAL52]", "number":"AB252195-CMP02", "productcode":"AB237713" } ] } } }
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GITR also known as TNFRSF18 is a 241 amino acid protein with a mass of approximately 27 kDa. It belongs to the tumor necrosis factor receptor superfamily. GITR is highly expressed on activated T cells and regulatory T cells (Tregs). The gene encoding GITR is located on chromosome 1 in humans. High surface expression is also observed in immune tissues such as the thymus spleen and lymph nodes playing an important role in immune responses.
Biological function summary

GITR acts as a costimulatory molecule that enhances T cell activation and proliferation. It does not function as part of a complex but interacts directly with ligand GITRL triggering downstream signaling cascades. This interaction is key in the modulation of immune responses notably in enhancing the activity of effector T cells and regulating Treg functions. Activation of GITR can reduce Treg-mediated suppression leading to enhanced immune responses.

Pathways

The mechanistic role of GITR involves NF-kB and MAPK signaling pathways. Through these GITR impacts immune responses by stimulating the production of cytokines and promoting cell survival and proliferation. GITR signaling intersects with pathways involving proteins such as NF-kB further integrating with the immune system's regulation crescendo.

GITR appears to play a role in autoimmune conditions like rheumatoid arthritis and potential cancer immunotherapy. In autoimmune diseases GITR modulates immune activity influencing the balance between inhibition and activation of T cells. In oncology GITR targeting aims to enhance immune responses against tumors. Through these conditions GITR shows connections to proteins such as CTLA-4 which also contributes to immune regulatory processes.
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Product protocols

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Target data

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer management and research 12:8015-8022 PubMed32943934

2020

Moxibustion Enhances Chemotherapy of Breast Cancer by Affecting Tumor Microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Ning Xue,Xingli Fu,Yin Zhu,Nili Da,Jianbin Zhang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com