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Mature Neuron Marker (MAP2, NeuN, NFH, PSD95, Synaptophysin) Antibody Sampler Panel (ab218257) is part of the multiplex kits range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.

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Images

Western blot - Mature Neuron Marker (MAP2, NeuN, NFH, PSD95, Synaptophysin) Antibody Sampler Panel (AB218257), expandable thumbnail
  • Immunohistochemistry (Frozen sections) - Mature Neuron Marker (MAP2, NeuN, NFH, PSD95, Synaptophysin) Antibody Sampler Panel (AB218257), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Mature Neuron Marker (MAP2, NeuN, NFH, PSD95, Synaptophysin) Antibody Sampler Panel (AB218257), expandable thumbnail

Key facts

Target
MAP2
(See target data below)

Associated Products

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Target data

Function

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

Additional Targets

RBFOX3, NEFH, DLG4, SYP

Alternative names

Recommended products

Mature Neuron Marker (MAP2, NeuN, NFH, PSD95, Synaptophysin) Antibody Sampler Panel (ab218257) is part of the multiplex kits range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.

Key facts

Target
MAP2

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
+4°C

Notes

Mature Neuron Marker (MAP2, NeuN, NFH, PSD95, Synaptophysin) Antibody Sampler Panel ab218257 contains recombinant rabbit monoclonal antibodies against MAP2, NeuN, Neurofilament heavy polypeptide, PSD95, and Synaptophysin.

Since mature neurons are no longer able to divide their purpose focuses on receiving, processing, and transferring information in the central and peripheral nervous systems.

The antibodies in this panel were selected for their exceptional performance in IHC, alongside other applications. Please see the individual datasheets for additional information.


Explore our range of antibody sample panels designed to provide you with a variety of trial-size antibodies in a convenient and cost-effective format.

Carrier-free formulations of our recombinant antibodies are also available for easy conjugation to labels of your choice and for multiplex applications. Use our intuitive search and select carrier-free or your label of choice. For bespoke conjugations or large volumes email bespoke@abcam.com.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

Synaptophysin Neurofilament heavy polypeptide (NF-H) PSD95 MAP2 and NeuN are essential proteins in neuronal tissues. Synaptophysin a glycoprotein with a mass of approximately 38 kDa is expressed mainly in presynaptic vesicles. Neurofilament heavy polypeptide or NF-H is a component of the neuronal cytoskeleton with a mass of about 200 kDa found throughout neurons. PSD95 also called DLG4 is an important scaffold protein in synaptic junctions. MAP2 known for its expression in dendrites is vital for microtubule stabilization. NeuN also called Fox-3 is a well-known marker for mature neurons with high expression in the nuclei of post-mitotic neurons.

Biological function summary

These proteins play important roles in neuronal development structure and function. Synaptophysin participates in synaptic vesicle cycling aiding neurotransmitter release. NF-H as part of the neurofilament complex contributes to axonal caliber and stability. PSD95 organizes protein complexes at postsynaptic sites facilitating synaptic signaling. MAP2 stabilizes microtubules essential for dendritic morphology and transport. NeuN marking indicates post-mitotic functionally mature neurons useful in identifying neuronal populations through immunohistochemistry.

Pathways

These proteins integrate into critical signaling cascades in the nervous system. Synaptophysin and PSD95 play roles in synaptic transmission pathways influencing neurotransmitter release and postsynaptic receptor clustering. NF-H and MAP2 fit into the cytoskeletal dynamics pathway affecting neuronal branching and plasticity. NeuN serves as a neuronal marker particularly highlighting neurons in mature neural circuits. Through these pathways PSD95 often interacts with NMDA receptors while Synaptophysin forms complexes with SNARE proteins.

Associated diseases and disorders

Alterations in these proteins link to several neurological conditions. Synaptophysin changes associate with Alzheimer's disease where synaptic dysfunction occurs. NF-H accumulation relates to amyotrophic lateral sclerosis (ALS) contributing to axonal degeneration. In both cases proteins such as MAPT (tau) and TDP-43 interplay with these alterations. Synaptic and cytoskeletal dysfunction in these diseases underlines the importance of biomarkers like NeuN and MAP2 in clinical research and diagnostics.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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