Acetate Assay Kit (Colorimetric)

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Acetate also known as acétate or acetae refers to the conjugate base of acetic acid and carries a molecular weight of approximately 59.04 g/mol. It is ubiquitously expressed across various tissues and cellular compartments playing a role in many metabolic processes. Acetate is produced primarily in the liver and is also present in the bloodstream contributing to its availability across diverse biological systems. Its ubiquitous distribution highlights its versatile role in cellular functions where it contributes as a substrate for biosynthesis.

Biological function summary

Many metabolic processes utilize acetate serving as an important building block in the synthesis of fatty acids and cholesterol. It is not typically associated with a complex but it collaborates with coenzymes and enzymes to drive biosynthetic reactions. For instance acetate acts as a precursor in the formation of acetyl-CoA an essential molecule in energy production and lipid synthesis. The convergence of acetate in such biochemical processes highlights its importance in maintaining cellular energy balance and material synthesis.

Pathways

Acetate prominently features in the acetyl-CoA biosynthesis pathway an important conduit for energy production. This pathway integrates acetate into cycles like the citric acid cycle where it partners with enzymes like citrate synthase. Another significant connection exists with the lipid biosynthesis pathway where acetate is converted into fatty acids relating closely with acetyl-CoA carboxylase. These pathways highlight the centrality of acetate in both energy provision and cell membrane synthesis affirming its integral role in cell metabolism.

Associated diseases and disorders

Acetate influences metabolic conditions such as diabetes and obesity due to its role in lipid biosynthesis and energy metabolism. These conditions relate to alterations in acetate metabolism often involving dysregulation of acetyl-CoA levels. Additionally acetate is associated with cancer proliferation where increased acetate metabolism supports the rapid growth of cancer cells. The involvement of enzymes like acetyl-CoA synthetase 2 in these diseases underlines the enzymatic control of acetate's role in pathological states showing its broader impact on health and disease.