Acetylcholinesterase Inhibitor Screening Kit (Colorimetric)
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(1 Publication)
Acetylcholinesterase Inhibitor Screening Kit ab283363 is used for the screening/characterizing of Acetylcholinesterase inhibitors.
Individual kit components also available for purchase with a minimum order of 20 units. Contact us to discuss your needs.
View Alternative Names
Acetylcholinesterase, AChE, ACHE
- FuncS
Supplier Data
Functional Studies - Acetylcholinesterase Inhibitor Screening Kit (Colorimetric) (AB283363)
Inhibition of Acetylcholinesterase activity by Donepezil. IC50 of Donepezil was calculated to be 31.5 ± 2.3 nM.
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Reactivity data
Product details
Acetylcholinesterase is the main cholinesterase enzyme in the nervous system. It is responsible for the hydrolysis of acetylcholine and some other choline esters that function as neurotransmitters. AChE is highly expressed in both the brain and the peripheral nervous system. It is especially enriched at neuromuscular junctions, where its activity serves to terminate synaptic transmission between motor neurons and skeletal muscles. Reversible inhibitors of AChE (such as donepezil, rivastigmine and galantamine) are commonly used in the treatment of Alzheimer's Disease and other neurodegenerative disorders. However, irreversible inhibitors of AChE tend to be extremely poisonous, causing muscular paralysis, convulsions, bronchial constriction and eventual death by asphyxia.
This product is manufactured by BioVision, an Abcam company and was previously called K197 Acetylcholinesterase Inhibitor Screening Kit (Colorimetric). K197-100 is the same size as the 100 test size of ab283363.
The Safety Datasheet for this product has been updated for certain countries. Please check the current version in the Support and downloads section.
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Properties and storage information
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Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Acetylcholinesterase is essential for maintaining neurotransmission dynamics by ensuring timely acetylcholine breakdown. It does not function as part of a larger enzyme complex but its activity is necessary for efficient synaptic signaling in the nervous system. This enzymatic action prevents continuous stimulation of muscles and nerves by rapidly degrading acetylcholine thereby ensuring proper muscle contraction and cognitive processes.
Pathways
Acetylcholinesterase participates significantly in the cholinergic system. It influences cholinergic signaling pathways by inactivating acetylcholine after its release into the synaptic cleft. This function aligns acetylcholinesterase closely with receptors like nicotinic and muscarinic acetylcholine receptors. It indirectly affects signal transduction pathways that involve these receptors with potential downstream effects on ion channels and intracellular messengers.
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Publications (1)
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Pharmaceutics 14: PubMed35214100
2022
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Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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