The Albumin Creatinine Ratio Assay Kit (ab241018) provides a simple, sensitive, and high throughput adaptable assay that detects albumin.
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- Frontiers in immunology 14:12058342023Dapagliflozin alleviates renal inflammation and protects against diabetic kidney diseases, both dependent and independent of blood glucose levels.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnxiang Cai,Jianxiao Shen,Xiaoqian Yang,Xinghua Shao,Leyi Gu,Shan Mou,Xiajing ChePubMed 38022502
- International journal of molecular sciences 24:2023Metalloporphyrins Reduce Proteinuria in Podocyte Immune Injury: The Role of Metal and Porphyrin Moieties.Applications:Unspecified applicationReactive species:Unspecified reactive speciesElias A Lianos,Gia Nghi Phung,Michelle Foster,Jianping Zhou,Mukut SharmaPubMed 37628958
- NPJ Regenerative medicine 7:152022Telomerase is required for glomerular renewal in kidneys of adult mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMargo Montandon,Tynhinane Hamidouche,Lucile Yart,Lou C Duret,Catherine Pons,Nicolas Soubeiran,Mélanie Pousse,Ludovic Cervera,Valérie Vial,Julien Fassy,Olivier Croce,Eric Gilson,Marina ShkreliPubMed 35149726
Key facts
- Detection method
Fluorescent
- Sample types
Saliva, Urine, Serum
Target data
Function
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (PubMed:19021548). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017).
Alternative names
Albumin, PRO2044, PRO1708, PRO0903, PRO2619, PRO2675, UNQ696/PRO1341, GIG42, GIG20, ALB
What's included?
Recommended products
The Albumin Creatinine Ratio Assay Kit (ab241018) provides a simple, sensitive, and high throughput adaptable assay that detects albumin.
Alternative names
Albumin, PRO2044, PRO1708, PRO0903, PRO2619, PRO2675, UNQ696/PRO1341, GIG42, GIG20, ALB
Key facts
- Detection method
Fluorescent
- Sample types
Saliva, Urine, Serum
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Storage information
-20°C
Notes
The Albumin Creatinine Ratio Assay Kit (ab241018) provides a simple, sensitive, and high throughput adaptable assay that detects albumin (detection range: 0.02- 2.5 mg/mL), creatinine (detection range: 0.002 -0.5 mg/mL) and Albumin-to-creatinine ratio.
The ACR ratio is determined in two steps: First, albumin is determined by using a probe (ab580) that specifically recognizes albumin (Ex/Em = 600/630 nm). Second, creatinine is converted to sarcosine via enzymatic reactions. Arcosine is specifically oxidized generating a product that reacts with a probe producing a chromophore that can be detected at 570 nm.
This product is manufactured by BioVision, an Abcam company and was previously called K551 Albumin-to-Creatinine Ratio (ACR). K551-100 is the same size as the 100 test size of ab241018.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Albumin/Creatinine often abbreviated as the albumin to creatinine ratio (ACR) serves as an important marker in the body. Albumin is a plasma protein with a molecular weight of approximately 66.5 kDa. It is synthesized in the liver and widely expressed in the blood while creatinine a breakdown product of creatine phosphate is a small molecule produced in the muscles and excreted in urine. The albumin/creatinine ratio measures these levels in urine to assess excretion balance and renal function.
- Biological function summary
The albumin and creatinine levels help evaluate kidney function and filtration efficiency. Albumin signifies the presence of larger proteins in urine when normal kidney filtering mechanisms are impaired. The presence and concentration of creatinine meanwhile reflect waste removal efficacy. The albumin/creatinine ratio provides a reliable estimation of microalbuminuria which is an elevation in urinary albumin considered indicative of early kidney damage. This ratio is not directly part of a complex but offers insight into the normal physiological role of kidneys.
- Pathways
Albumin/creatinine measurements relate primarily to renal regulation and excretory pathways. They indicate how well glomeruli the filtering units in kidneys function relative to proteins and byproducts' reabsorption or excretion. These measurements tie to pathways involving renin-angiotensin-aldosterone system and vasopressin signaling with contacts to proteins like nephrin and podocin that maintain the integrity of the glomerular filtration barrier.
- Associated diseases and disorders
Albumin/creatinine ratios possess strong correlations with conditions such as diabetes and hypertension. High levels of this ratio suggest an increased risk for diabetic nephropathy where persistent albuminuria develops as the disease progresses. In hypertension albuminuria signifies the strain and damage on kidney structures often exacerbating chronic kidney disease. This ratio is additionally linked with angiotensin-converting enzyme (ACE) frequently altered in these conditions to manage blood pressure and minimize kidney damage.
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3 product images
Functional Studies - Albumin Creatinine Ratio Assay Kit (ab241018)
BSA Standard Curve.
Functional Studies - Albumin Creatinine Ratio Assay Kit (ab241018)
Creatinine Standard Curve.
Functional Studies - Albumin Creatinine Ratio Assay Kit (ab241018)
Estimation of ACR in human urine in diabetic (1) and non-diabetic donors (2, and 3).
For Albumin, 50 μL of undiluted samples and for Creatinine, 30 μL of diluted samples (100 times diluted using Creatinine Assay Buffer) were assayed following the kit protocol.
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