Branched Chain Amino Acid Assay Kit / BCAA Assay Kit

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Branched chain amino acids (BCAAs) are a group of essential amino acids including leucine isoleucine and valine. People also refer to BCAAs as branched chain amino. With a combined molecular mass of around 131–131.18 Da each they exhibit a unique branched chain structure. BCAAs are prevalent throughout the body especially in muscle tissue where they account for a significant portion of total amino acids. The BCAA name refers to their branched aliphatic side chain a structural characteristic that differentiates them from other amino acids used in protein synthesis.

Biological function summary

Branched chain amino acids serve important roles beyond being building blocks for protein. BCAAs as part of a complex metabolic family play a critical role in muscle metabolism and energy production. They are involved in protein synthesis by activating key pathways and regulators like mTOR a well-known protein complex responsible for cell growth and proliferation. By serving as substrates for gluconeogenesis and energy BCAAs impact energy homeostasis particularly during periods of increased physical demand when body muscles require amino chain supplement.

Pathways

Branched chain amino acids engage with various metabolic processes and signaling pathways important for maintaining homeostasis. A notable involvement lies in the mTOR signaling pathway where BCAAs especially leucine act as significant regulators influencing energy metabolism and protein synthesis. The insulin signaling pathway also features interactions with BCAAs highlighting a connection between these amino acids and metabolic regulators like insulin reflecting their role in energy balance and nutrient sensing within cells.

Associated diseases and disorders

Altered levels of branched chain amino acids link to several metabolic disorders particularly diabetes and obesity. Elevated BCAA levels in the bloodstream associate with insulin resistance a condition precursory to type 2 diabetes indicating a potential biomarker role in this pathway disturbance. Additionally obesity research shows a relationship between high BCAA levels and metabolic dysfunctions. The interplay between BCAAs and proteins like insulin and mTOR provides insights into their contribution to the pathophysiology of these metabolic conditions.