AB102488
Caspase Family Colorimetric Substrate Kit II Plus
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Abcam's Caspase Family Colorimetric Substrate Kit II Plus provides ready-to-use colorimetric substrates for members of caspase family proteases.
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Product details
Abcam's Caspase Family Colorimetric Substrate Kit II Plus provides ready-to-use colorimetric substrates for members of caspase family proteases. All substrates are provided in liquid ready-to-use form.
Visit our FAQs page for tips and troubleshooting.
This product is manufactured by BioVision, an Abcam company and was previously called K138 Caspase Colorimetric Substrate Set II Plus. K138-9-25 is the same size as the 25 test size of ab102488.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
What's included?
{ "values": { "25Test": { "sellingSize": "25 Test", "publicAssetCode":"ab102488-25Test", "assetComponentDetails": [ { "size":"1 x 100 mL", "name":"Lysis Buffer IV", "number":"AB102488-CMP12", "productcode":"" }, { "size":"1 x 20 mL", "name":"Caspase 2X Reaction Buffer", "number":"AB102488-CMP01", "productcode":"" }, { "size":"1 x 200 mL", "name":"Dilution Buffer II", "number":"AB102488-CMP10", "productcode":"" }, { "size":"1 x 400 µL", "name":"DTT I", "number":"AB102488-CMP13", "productcode":"" }, { "size":"1 x 125 µL", "name":"Caspase 8 Substrate", "number":"AB102488-CMP04", "productcode":"" }, { "size":"1 x 125 µL", "name":"Ac-VDVAD-pNA", "number":"AB102488-CMP06", "productcode":"" }, { "size":"1 x 125 µL", "name":"Caspase 9 Substrate", "number":"AB102488-CMP05", "productcode":"" }, { "size":"1 x 125 µL", "name":"Caspase 4 Substrate", "number":"AB102488-CMP09", "productcode":"" }, { "size":"1 x 125 µL", "name":"Ac-WEHD-pNA", "number":"AB102488-CMP07", "productcode":"" }, { "size":"1 x 125 µL", "name":"Ac-VEID-pNA", "number":"AB102488-CMP11", "productcode":"" }, { "size":"1 x 125 µL", "name":"YVAD-pNA", "number":"AB102488-CMP08", "productcode":"" }, { "size":"1 x 125 µL", "name":"DEVD-pNA", "number":"AB102488-CMP03", "productcode":"" }, { "size":"1 x 125 µL", "name":"AEVD-pNA", "number":"AB102488-CMP02", "productcode":"" } ] } } }
Properties and storage information
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
-20°C
Product protocols
- Visit the General protocols
- Visit the Troubleshooting
- Download websiteProtocolBooklet|en
Target data
Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed : 18723680, PubMed : 20566630, PubMed : 23650375, PubMed : 35338844, PubMed : 35446120, PubMed : 7596430). Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed : 18723680, PubMed : 20566630, PubMed : 23650375, PubMed : 7596430). At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond (PubMed : 10497198, PubMed : 16374543, PubMed : 7596430, PubMed : 7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain (By similarity). Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively) (PubMed : 7596430). Cleaves and inactivates interleukin-18 (IL18) (PubMed : 37993714, PubMed : 9334240). Involved in the cleavage of huntingtin (PubMed : 8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed : 21357690). Cleaves DSG2 in response to apoptosis resulting in a loss of full length DSG2 at desmosome cell junctions and subsequent loss of cell-cell adhesion (PubMed : 17559062). Also cleaves JUP in response to apoptosis (PubMed : 17559062). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed : 23152800). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed : 30878284). Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (PubMed : 35338844, PubMed : 35446120). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed : 23845944, PubMed : 33725486). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed : 36758104, PubMed : 36758106).
Additional targets
CASP1,CASP9,CASP8,CASP4
Alternative Names
CPP32, CASP3, Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, Protein Yama, SREBP cleavage activity 1, CPP-32, SCA-1, IL1BC, IL1BCE, CASP1, Caspase-1, CASP-1, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, p45, IL-1BC, ICE, IL-1 beta-converting enzyme, MCH6, CASP9, Caspase-9, CASP-9, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, ICE-like apoptotic protease 6, APAF-3, ICE-LAP6, MCH5, CASP8, Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, FLICE, MACH, ICH2, CASP4, Caspase-4, CASP-4, ICE and Ced-3 homolog 2, ICE(rel)-II, Mih1, Protease TX, ICH-2
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