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AB150667

Elastic Stain Kit (Verhoeff Van Gieson / EVG Stain)

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(57 Publications)

Elastic Stain Kit ab150667 uses a modified Verhoeff's Van Gieson / EVG stain to stain elastic fibers / elastin in tissue sections in histology.

- Use for connective tissue fiber analysis
- Suitable for Formalin-Fixed Paraffin-Embedded (FFPE) sections
- Includes ready-to-use solutions of Cresyl Echt Violet, Luxol Fast Blue, Lithium carbonate and 70% alcohol
- Cited in over 40 publications
3 Images
Histology - Elastic Stain Kit (Verhoeff Van Gieson / EVG Stain) (AB150667)
  • Histology

Lab

Histology - Elastic Stain Kit (Verhoeff Van Gieson / EVG Stain) (AB150667)

ab150667 (Elastic (connective tissue stain)) staining elastic fibres (blue/black) and collagen (red/pink) in formalin fixed paraffin embedded normal human lung. Muscle and other tissues appear yellow.

*Tissue obtained from the Human Research Tissue Bank, supported by the NIHR Cambridge Biomedical Research Centre.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Elastic Stain Kit (Verhoeff Van Gieson / EVG Stain) (AB150667)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Elastic Stain Kit (Verhoeff Van Gieson / EVG Stain) (AB150667)

ab150667 Elastic Stain Kit (Connective Tissue Stain) staining formalin-fixed-paraffin embedded human artery.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Elastic Stain Kit (Verhoeff Van Gieson / EVG Stain) (AB150667)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Elastic Stain Kit (Verhoeff Van Gieson / EVG Stain) (AB150667)

Staining of Uterus with ab150667 - Elastic Stain Kit (Modified Verhoff's).

Key facts

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Product details

Elastic Stain Kit ab150667 uses a modified Verhoeff's Van Gieson / EVG stain to stain elastic fibers / elastin in tissue sections in histology. Staining of elastic tissue is useful in cases of emphysema (atrophy of elastic tissue), arteriosclerosis (thinning and loss of elastic fibers) and various other vascular diseases.

Other products for staining tissue sections

Find more kits and reagents in the special stains guide, or products for antigen retrieval, blocking, signal amplification, visualization, counterstaining, and mounting in the IHC kits and reagents guide.

Staining Interpretation

Elastic fibers Black to Blue/Black
Nuclei Blue to Black
Collagen Red
Muscle & Other Yellow

Control Tissue: Lung or any vascular tissue.

Other Notes

Please note, the 125 mL selling size, was previously described as 100 Test. There has been no change to the physical product.

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What's included?

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Ambient
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Elastin also known as tropoelastin is an important protein in connective tissues contributing to the elasticity and flexibility of tissues like skin lungs and arteries. Elastin has a molecular weight of approximately 70 kDa. This protein is primarily expressed in organs that require elastic recoil for normal function. The highest concentrations of elastin can be found in elastic fibers which are critical components of the extracellular matrix of tissues like blood vessels lungs and skin. Elastin fibers can be visualized using specific staining techniques in histological studies such as elastin histology or elastic tissue stains.
Biological function summary

Elastin provides structural integrity and elasticity to connective tissues. It functions as a major component of elastic fibers which are complex structures formed in association with other proteins including fibrillin and microfibril-associated glycoproteins. These components work together to form a supportive mesh in the extracellular matrix. Elastin’s unique properties allow tissues to extend and return to their original shape maintaining tissue flexibility and resilience. Elastic fibers observed through various elastin staining methods help notice elastin’s distribution and organization within tissues.

Pathways

Elastin involves mainly in the extracellular matrix organization and the vascular smooth muscle contraction pathways. Elastin interacts with several proteins such as fibrillin-1 forming complex networks essential for maintaining vascular integrity and elasticity. Matrix metalloproteinases for instance play roles in the remodeling of the extracellular matrix involving elastin degradation and renewal processes. The regulation and interaction of these pathways are key to understanding how elastin supports normal tissue architecture and function.

Elastin associates with conditions like cutis laxa and Williams syndrome. Mutations in the elastin gene can lead to cutis laxa a disorder that affects the connective tissue causing loose saggy skin. Williams syndrome is linked to elastin gene deletions and affects cardiovascular connective tissue and neurodevelopmental aspects. These disorders highlight elastin's importance in maintaining healthy tissue structure and function. Associated proteins like fibrillin and lysyl oxidase contribute to understanding these conditions further linking elastin with broader connective tissue abnormalities.
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Product protocols

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Target data

See full target information Elastin
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Publications (57)

Recent publications for all applications. Explore the full list and refine your search

Cardiovascular diabetology 24:223 PubMed40399937

2025

Perivascular adipose tissue dysfunction contributes to thoracic aortic aneurysm development.

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Zhenguo Wang,Wenjuan Mu,Ruiyan Xu,Juan Zhong,Wenhao Xiong,Xiangjie Zhao,Xiubin Liang,Yanhong Guo,Jifeng Zhang,Zhi-Sheng Jiang,Bo Yang,Y Eugene Chen,Lin Chang

Journal of inflammation research 18:1377-1394 PubMed39897521

2025

Integrative Bioinformatics Analysis to Identify Key Ferroptosis-Related Genes and Immune Infiltration in Aortic Aneurysm and Dissection: Implication of PTGS2.

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Weiwei An,Jun Luo,Cheng Zhang,Qingzhong Xiao

Microbiology spectrum 12:e0177624 PubMed39315850

2024

The role of dysbiotic gut mycobiota in modulating risk for abdominal aortic aneurysm.

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Guixiang Yao,Xinjie Zhang,Tongxue Zhang,Jiajia Jin,Zihan Qin,Xiaoyu Ren,Xiaowei Wang,Shucui Zhang,Xianlun Yin,Zhenyu Tian,Yun Zhang,Jingyong Zhang,Zhe Wang,Qunye Zhang

Journal of clinical medicine 13: PubMed39200916

2024

Exploring the Potential of Saphenous Vein Grafts Ex Vivo: A Model for Intimal Hyperplasia and Re-Endothelialization.

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Nur A'tiqah Haron,Mohamad Fikeri Ishak,Muhammad Dain Yazid,Ubashini Vijakumaran,Roszita Ibrahim,Raja Zahratul Azma Raja Sabudin,Hafiza Alauddin,Nur Ayub Md Ali,Hairulfaizi Haron,Muhammad Ishamuddin Ismail,Mohd Ramzisham Abdul Rahman,Nadiah Sulaiman

Cardiovascular research 120:1768-1779 PubMed39056563

2024

Inhibition of endothelial-to-mesenchymal transition in a large animal preclinical arteriovenous fistula model leads to improved remodelling and reduced stenosis.

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Species

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Yang Xu,Adam Korayem,Ana S Cruz-Solbes,Nirupama Chandel,Tomoki Sakata,Renata Mazurek,Spyros A Mavropoulos,Taro Kariya,Tadao Aikawa,Kelly P Yamada,Valentina D'Escamard,Bhargavi V'Gangula,Andrew H Baker,Lijiang Ma,Johan L M Björkegren,Valentin Fuster,Manfred Boehm,Kenneth M Fish,Rami Tadros,Kiyotake Ishikawa,Jason C Kovacic

International journal of biological sciences 20:2092-2110 PubMed38617538

2024

Colchicine Blocks Abdominal Aortic Aneurysm Development by Maintaining Vascular Smooth Muscle Cell Homeostasis.

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Min Chen,Dafeng Yang,Yangzhao Zhou,Chongzhe Yang,Wenhui Lin,Jie Li,Jitao Liu,Jiamin Ye,Wenhui Huang,Wentao Ma,Wei Li,Jiyan Chen,Ying Zhang,Guo-Ping Shi,Jianfang Luo,Jie Li,Songyuan Luo

Atherosclerosis 391:117492 PubMed38461759

2024

Antisense oligonucleotide targeting hepatic Serum Amyloid A limits the progression of angiotensin II-induced abdominal aortic aneurysm formation.

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Preetha Shridas,Ailing Ji,Andrea C Trumbauer,Victoria P Noffsinger,Luke W Meredith,Frederick C de Beer,Adam E Mullick,Nancy R Webb,Dennis G Karounos,Lisa R Tannock

Journal of gastroenterology 59:250-262 PubMed38242997

2024

Impact of intratumoral microbiome on tumor immunity and prognosis in human pancreatic ductal adenocarcinoma.

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Species

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Shohei Abe,Atsuhiro Masuda,Tomonori Matsumoto,Jun Inoue,Hirochika Toyama,Arata Sakai,Takashi Kobayashi,Takeshi Tanaka,Masahiro Tsujimae,Kohei Yamakawa,Masanori Gonda,Shigeto Masuda,Hisahiro Uemura,Shinya Kohashi,Noriko Inomata,Kae Nagao,Yoshiyuki Harada,Mika Miki,Yosuke Irie,Noriko Juri,Testuhisa Ko,Yusuke Yokotani,Yuki Oka,Shogo Ota,Maki Kanzawa,Tomoo Itoh,Toshio Imai,Takumi Fukumoto,Eiji Hara,Yuzo Kodama

International journal of molecular sciences 24: PubMed37958985

2023

Vasculoprotective Potential of Baicalein in Angiotensin II-Infused Abdominal Aortic Aneurysms through Inhibiting Inflammation and Oxidative Stress.

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Species

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Erna Sulistyowati,Shang-En Huang,Tsung-Lin Cheng,Yu-Ying Chao,Chia-Yang Li,Ching-Wen Chang,Meng-Xuan Lin,Ming-Chung Lin,Jwu-Lai Yeh

Journal of cardiovascular pharmacology 82:458-469 PubMed37721971

2023

Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by Regulating miR-143-5p /CCL20.

Applications

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Species

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Yuejin Li,Rougang Li,Yu Li,Guosan Li,Yiman Zhao,Houyu Mou,Yi Chen,Le Xiao,Kunmei Gong
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