Fructose Assay Kit (Fluorometric)

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Fructose often known as levulose is a simple sugar with a molecular mass of 180.16 g/mol. It is a monosaccharide found in many plants where it is frequently bonded with glucose to form the disaccharide sucrose. Fructose is absorbed directly into the bloodstream during digestion. Primarily expressed in the liver intestine and kidney fructose undergoes phosphorylation by fructokinase resulting in fructose-1-phosphate an essential step in fructose metabolism.

Biological function summary

Fructose serves as a fuel source and influences lipogenesis and insulin sensitivity. It does not operate as part of a complex but acts singularly in its metabolic functions. Fructose metabolism primarily handled by the liver impacts energy homeostasis and lipid synthesis with significant implications for glucose homeostasis. The fructose assay helps in quantifying fructose levels useful in both research and clinical settings to assess metabolic conditions.

Pathways

Fructose plays a significant role in the glycolytic and gluconeogenesis pathways. Fructose metabolism feeds into the glycolytic pathway where it gets converted to intermediates like dihydroxyacetone phosphate. This conversion connects fructose metabolism indirectly to gluconeogenesis. Additionally proteins such as hexokinase and aldolase B are integral to these processes facilitating the phosphorylation and cleavage necessary for further metabolic reactions.

Associated diseases and disorders

Fructose relates closely to conditions like non-alcoholic fatty liver disease and metabolic syndrome. Excessive fructose metabolism can lead to lipid accumulation in the liver highlighting its link to non-alcoholic fatty liver disease. Metabolic syndrome characterized by insulin resistance and obesity often involves dysregulated fructose intake. Proteins like insulin and leptin interact intricately with fructose metabolism influencing these disorders and offering potential targets for therapeutic intervention.