Acetylation of histones such histone H3 has been involved in the regulation of chromatin structure and the recruitment of transcription factors to gene promoters.
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- International journal of molecular sciences 24:2023Orthodontic Compression Enhances Macrophage M2 Polarization via Histone H3 Hyperacetylation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYao Wang,Sabine Groeger,Jiawen Yong,Sabine RufPubMed 36834533
- Genes 13:2022Pantothenate and L-Carnitine Supplementation Improves Pathological Alterations in Cellular Models of KAT6A Syndrome.Applications:Unspecified applicationReactive species:Unspecified reactive speciesManuel Munuera-Cabeza,Mónica Álvarez-Córdoba,Juan M Suárez-Rivero,Suleva Povea-Cabello,Irene Villalón-García,Marta Talaverón-Rey,Alejandra Suárez-Carrillo,Diana Reche-López,Paula Cilleros-Holgado,Rocío Piñero-Pérez,José A Sánchez-AlcázarPubMed 36553567
- Cells 11:2022Insights into the Histone Acetylation-Mediated Regulation of the Transcription Factor Genes That Control the Embryogenic Transition in the Somatic Cells of Arabidopsis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJoanna Morończyk,Agnieszka Brąszewska,Barbara Wójcikowska,Karolina Chwiałkowska,Katarzyna Nowak,Anna M Wójcik,Mirosław Kwaśniewski,Małgorzata D GajPubMed 35269485
- International journal of molecular sciences 21:2020Food for Bone: Evidence for a Role for Delta-Tocotrienol in the Physiological Control of Osteoblast Migration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLavinia Casati et. al.PubMed 32629979
- Melanoma research 28:521-5262018The BET-bromodomain inhibitor JQ1 mitigates vemurafenib drug resistance in melanoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBei Zhao,Xiankui Cheng,Xiyuan ZhouPubMed 30192303
- PloS one 13:e01934642018Transgenerational effects of prenatal restricted diet on gene expression and histone modifications in the rat.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJoanna Nowacka-Woszuk et. al.PubMed 29474484
- American journal of physiology. Lung cellular and 310:L700-102016miR-185 mediates lung epithelial cell death after oxidative stress.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDuo Zhang et. al.PubMed 26747785
- PloS one 9:e1076592014Feeding a high-concentrate corn straw diet induced epigenetic alterations in the mammary tissue of dairy cows.Applications:FuncSReactive species:CowGuozhong Dong,Min Qiu,Changjin Ao,Jun Zhou, Khas-Erdene,Xi Wang,Zhu Zhang,You YangPubMed 25222274
- Renal failure 36:1078-822014Global and specific histone acetylation pattern in patients with Balkan endemic nephropathy, a worldwide disease.
Key facts
- Detection method
- Colorimetric
- Sample types
- Tissue, Suspension cells, Adherent cells
- Reactive species
- Mouse, Human
- Range
- 2 - 100 ng
- Assay time
- 2h 30m
- Sensitivity
- = 2 ng
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Acetylation of histones such histone H3 has been involved in the regulation of chromatin structure and the recruitment of transcription factors to gene promoters.
Key facts
- Detection method
- Colorimetric
- Sample types
- Tissue, Suspension cells, Adherent cells
- Reactive species
- Mouse, Human
- Range
- 2 - 100 ng
- Assay time
- 2h 30m
- Assay Platform
- Microplate reader
- Sensitivity
- = 2 ng
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- Multi
- Appropriate long-term storage conditions
- Multi
- Storage information
- Please refer to protocols
Notes
Acetylation of histones such histone H3 has been involved in the regulation of chromatin structure and the recruitment of transcription factors to gene promoters. HATs (histone acetyltransferases) and HDACs (histone deacetylases) play a critical role in controlling histone H3 actylation. Histone acetylation is tightly involved in cell cycle regulation, cell proliferation and apoptosis. The reversible lysine acetylation of histone H3 may play a vital role in the regulation of many cellular processes including chromatin dynamics and transcription, gene silencing, cell cycle progression, apoptosis, differentiation, DNA replication and repair, nuclear import and neuronal repression.
Histone H3 Total Acetylation Detection Fast Kit (Colorimetric) allows the user to colorimetrically detect and quantify if histone H3 is acetylated. The kit is ready-to-use and provides all the essential components needed to carry out a successful assay experiment. ab115124 is suitable for specifically measuring total histone H3 acetylation using a variety of mammalian cells including fresh and frozen tissues, and cultured adherent and suspension cells.
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Nowacka-Woszuk, Joanna et al., PloS one vol. 13,2 e0193464., Fig 4, doi:10.1371/journal.pone.0193464Functional Studies - Histone H3 Total Acetylation Detection Fast Kit (Colorimetric) (ab115124)
The differences in H3 acetylation level in fetal livers (female fetuses aged 19 dpc) from F1, F2, and F3 generations. measured with Histone Extraction Kit ab113476. Histones were prepared using ab115124
Asterisk indicate a significant difference between the respective C and R groups: ∗∗ P < 0.01; NS not significant. Data presented as the means ± SE (n = 6 per group).
Functional Studies - Histone H3 Total Acetylation Detection Fast Kit (Colorimetric) (ab115124)
Acetylation Histone 3 per mg of extracted histones from murine tissue preparations (extracted using Histone Extraction Kit ab113476; 20-500 ng per well) (duplicates +/- SD).
Functional Studies - Histone H3 Total Acetylation Detection Fast Kit (Colorimetric) (ab115124)
Standard curve with background signal subtracted (duplicates; +/- SD).
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