Mucicarmine (Mucin Stain) is intended for use in the histological visualization of acid mucopolysaccharides in tissue sections.
Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999).
MUC2, MUC1, MUC16, MUC5B
MUC5, MUC5AC, Mucin-5AC, MUC-5AC, Gastric mucin, Major airway glycoprotein, Tracheobronchial mucin, TBM
Mucicarmine (Mucin Stain) is intended for use in the histological visualization of acid mucopolysaccharides in tissue sections.
Mucicarmine (Mucin Stain) is intended for use in the histological visualization of acid mucopolysaccharides in tissue sections. This product is useful in distinguishing mucin negative undifferentiated squamous cell lesions from mucin positive adenocarcinomas. In addition, this product will stain the mucopolysaccharide capsule of Cryptococcus neoformans.
Other products for staining tissue sections
Find more kits and reagents in the special stains guide, or products for antigen retrieval, blocking, signal amplification, visualization, counterstaining, and mounting in the IHC kits and reagents guide.
Staining InterpretationMucin | Pink/Red |
Capsule of Cryptococcus | Red |
Nuclei | Blue to Green |
Other Tissue Components | Yellow |
Control Tissue: Colon, Intestine, Bronchial Epithelial Cells.
Acid mucopolysaccharides commonly called glycosaminoglycans (GAGs) are long unbranched polysaccharides. They have high molecular weight often ranging from hundreds of kilodaltons. These molecules are mainly composed of repeating disaccharide units with one of the sugars usually being an amino sugar like N-acetylglucosamine or N-acetylgalactosamine. Acid mucopolysaccharides express largely in connective tissues across the body such as cartilage bone skin and the extracellular matrix.
Acid mucopolysaccharides function as key structural components in tissues aiding in resilience and tensile strength. They are also part of proteoglycan complexes where they covalently bind to core proteins. This binding contributes significantly to the physical properties of connective tissues like cartilage where they help to withstand compressive forces. Furthermore acid mucopolysaccharides participate in cellular signaling processes impacting cell growth and repair.
These complex polysaccharides play important roles within the extracellular matrix organization and glycosaminoglycan degradation pathways. Their interactions with proteins such as collagen and elastin support tissue structure and flexibility. Furthermore enzymes like hyaluronidase and chondroitinase regulate their breakdown impacting tissue remodeling and cellular communication.
Abnormalities in acid mucopolysaccharides metabolism or storage can lead to mucopolysaccharidoses a group of lysosomal storage disorders. For example Hurler syndrome arises due to the accumulation of dermatan sulfate and heparan sulfate. The disease involves deficient activity of the enzyme alpha-L-iduronidase causing significant connective tissue malfunction. Such disorders may also connect with abnormal signaling through proteins like fibroblast growth factors influencing various developmental and degenerative conditions.
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ab150677 Mucicarmine Stain Kit (Mucin Stain) staining formalin-fixed-paraffin embedded human GI tract.
Staining using ab150677 - Mucicarmine Stain Kit.
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