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Mucicarmine (Mucin Stain) is intended for use in the histological visualization of acid mucopolysaccharides in tissue sections.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Mucicarmine Stain Kit (Mucin Stain) (AB150677), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Mucicarmine Stain Kit (Mucin Stain) (AB150677), expandable thumbnail

Publications

Target data

Function

Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999).

Additional Targets

MUC2, MUC1, MUC16, MUC5B

Alternative names

What's included?

100 Test
Components
Bluing Reagent
1 x 125 mL
Hematoxylin (Modified Mayer's Solution)
1 x 125 mL
Mucicamine solution
1 x 125 mL
Tartrazine solution
1 x 125 mL

Recommended products

Mucicarmine (Mucin Stain) is intended for use in the histological visualization of acid mucopolysaccharides in tissue sections.

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Multi
Storage information
Please refer to protocols

Notes

Mucicarmine (Mucin Stain) is intended for use in the histological visualization of acid mucopolysaccharides in tissue sections. This product is useful in distinguishing mucin negative undifferentiated squamous cell lesions from mucin positive adenocarcinomas. In addition, this product will stain the mucopolysaccharide capsule of Cryptococcus neoformans.

Other products for staining tissue sections

Find more kits and reagents in the special stains guide, or products for antigen retrieval, blocking, signal amplification, visualization, counterstaining, and mounting in the IHC kits and reagents guide.

Staining Interpretation
MucinPink/Red
Capsule of Cryptococcus Red
NucleiBlue to Green
Other Tissue Components Yellow

Control Tissue: Colon, Intestine, Bronchial Epithelial Cells.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

Acid mucopolysaccharides commonly called glycosaminoglycans (GAGs) are long unbranched polysaccharides. They have high molecular weight often ranging from hundreds of kilodaltons. These molecules are mainly composed of repeating disaccharide units with one of the sugars usually being an amino sugar like N-acetylglucosamine or N-acetylgalactosamine. Acid mucopolysaccharides express largely in connective tissues across the body such as cartilage bone skin and the extracellular matrix.

Biological function summary

Acid mucopolysaccharides function as key structural components in tissues aiding in resilience and tensile strength. They are also part of proteoglycan complexes where they covalently bind to core proteins. This binding contributes significantly to the physical properties of connective tissues like cartilage where they help to withstand compressive forces. Furthermore acid mucopolysaccharides participate in cellular signaling processes impacting cell growth and repair.

Pathways

These complex polysaccharides play important roles within the extracellular matrix organization and glycosaminoglycan degradation pathways. Their interactions with proteins such as collagen and elastin support tissue structure and flexibility. Furthermore enzymes like hyaluronidase and chondroitinase regulate their breakdown impacting tissue remodeling and cellular communication.

Associated diseases and disorders

Abnormalities in acid mucopolysaccharides metabolism or storage can lead to mucopolysaccharidoses a group of lysosomal storage disorders. For example Hurler syndrome arises due to the accumulation of dermatan sulfate and heparan sulfate. The disease involves deficient activity of the enzyme alpha-L-iduronidase causing significant connective tissue malfunction. Such disorders may also connect with abnormal signaling through proteins like fibroblast growth factors influencing various developmental and degenerative conditions.

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2 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Mucicarmine Stain Kit (Mucin Stain) (ab150677), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Mucicarmine Stain Kit (Mucin Stain) (ab150677)

    ab150677 Mucicarmine Stain Kit (Mucin Stain) staining formalin-fixed-paraffin embedded human GI tract.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Mucicarmine Stain Kit (Mucin Stain) (ab150677), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Mucicarmine Stain Kit (Mucin Stain) (ab150677)

    Staining using ab150677 - Mucicarmine Stain Kit.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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