Phosphotungstic Acid Hematoxylin (PTAH) Stain Kit (Connective Tissue Stain)

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Connective tissue is a complex structural network that supports and connects other tissues and organs in the body. It is composed mainly of protein fibers such as collagen elastin and reticular fibers with a ground substance of proteoglycans and glycoproteins. Connective tissue varies in density and cellular composition and is abundant throughout the body. It is expressed in diverse forms like loose connective tissue dense connective tissue cartilage bone blood and lymph each with distinct cellular arrangements fulfilling specific mechanical roles.

Biological function summary

Connective tissue provides structural support protection and insulation to the body while also facilitating nutrient transport and waste removal. It plays an integral role in tissue repair and inflammation response. Connective tissue exists as part of a larger extracellular matrix complex interacting with cells through integrins and other cell-surface proteins. It serves as a scaffold for cellular attachment and migration significantly impacting the function of embedded cells like fibroblasts adipocytes and immune cells.

Pathways

Connective tissue is deeply involved in processes like the wound healing pathway and the inflammatory response pathway. Within these pathways it interacts with proteins such as matrix metalloproteinases (MMPs) which remodel extracellular matrix components during tissue repair. Connective tissue also connects with signaling molecules like cytokines which regulate the inflammatory response and influence tissue dynamics and repair mechanisms.

Associated diseases and disorders

Connective tissue abnormalities are implicated in conditions like Ehlers-Danlos syndrome and Marfan syndrome which involve defects in the structure or synthesis of connective tissue proteins. Mutations affecting collagen a major protein in connective tissue contribute to the development of these disorders. Additionally alterations in connective tissue can play a role in fibrosis and related diseases where excessive connective tissue deposition leads to organ dysfunction. Understanding connective tissue's role in these conditions aids in comprehending its impact on overall tissue integrity and function.