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AB150684

Reticulum Stain Kit (Connective Tissue Stain)

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(4 Publications)

The Reticulum Stain Kit (Connective Tissue Stain) is intended for use in histological demonstration of reticular fibers.
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Staining - Reticulum Stain Kit (Connective Tissue Stain) (AB150684)
  • Staining

Supplier Data

Staining - Reticulum Stain Kit (Connective Tissue Stain) (AB150684)

Staining in Liver using ab150684 - Reticulum Stain Kit.

Key facts

Sample types

Tissue sections

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Product details

The Reticulum Stain Kit (Connective Tissue Stain) is intended for use in histological demonstration of reticular fibers. The main function of reticular fibers is to provide support. They are normally found throughout the body, particularly in liver, lymph node, spleen and kidney. Ammoniacal silver stains are the most commonly used methods for demonstration of reticular fibers.

Other products for staining tissue sections

Find more kits and reagents in the special stains guide, or products for antigen retrieval, blocking, signal amplification, visualization, counterstaining, and mounting in the IHC kits and reagents guide.

Staining Interpretation

Reticulum Black
Nuclei Red

Control Tissue: Liver, Kidney, Lymph Node, Spleen

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What's included?

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
Multi
Storage information
Please refer to protocols
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Reticular fibers also known as reticulin fibers serve as a supportive scaffolding in connective tissues. They primarily consist of type III collagen a protein with a molecular mass that varies but is generally around 300 kDa. These fibers form intricate networks that are abundantly expressed in the extracellular matrix of several organs including the liver lymph nodes and bone marrow. Their unique structure permits a certain degree of flexibility and elasticity offering support to the surrounding cellular components.
Biological function summary

The structural framework provided by reticular fibers supports cellular organization in connective tissue environments. These fibers often associate with other extracellular matrix components such as glycoproteins and proteoglycans to form a complex that enhances the maintenance and resilience of connective tissue. They play an important role in filtering bodily fluids due to presence in lymphoid tissues like the spleen and lymph nodes where they aid in trapping particulates and pathogens.

Pathways

Type III collagen in reticular fibers functions within the complex processes of tissue organization and repair. Specifically they are part of the extracellular matrix pathway which includes interactions with other collagens and matrix metalloproteinases. Another related pathway is the wound healing pathway where type III collagen collaborates with fibronectin and type I collagen to facilitate tissue repair and regeneration.

Alterations in reticular fiber networks associate with certain conditions such as liver fibrosis and Ehlers-Danlos syndrome. In liver fibrosis excessive reticular fiber deposition occurs leading to tissue stiffness due to increased type III collagen production. In Ehlers-Danlos syndrome mutations in the genes coding for collagen can disrupt reticular fiber function affecting tissue elasticity and strength. In both conditions changes in other collagens like type I collagen are often observed which further complicate the tissue integrity and contribute to disease pathology.
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Product protocols

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Target data

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cancers 13: PubMed34203215

2021

Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia I Krupenko,Jaspreet Sharma,Halle M Fogle,Peter Pediaditakis,Kyle C Strickland,Xiuxia Du,Kristi L Helke,Susan Sumner,Sergey A Krupenko

Cells 10: PubMed33801626

2021

Effect of Muscle Cell Preservation on Viability and Differentiation of Hamstring Tendon Graft In Vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Kyu Lee,Sungsin Jo,Young Lim Lee,Subin Weon,Jun-Seob Song,Il-Hoon Sung,Tae-Hwan Kim

Cell reports 31:107475 PubMed32268085

2020

Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Haider M Hassan,Majdina Isovic,Bart Kolendowski,Natasha Bauer-Maison,Oladapo Onabote,Matthew Cecchini,Aaron Haig,Saman Maleki Vareki,T Michael Underhill,Joseph Torchia

Journal of the Endocrine Society 3:181-200 PubMed30620005

2019

Pituitary Pathology and Gene Expression in Acromegalic Cats.

Applications

Unspecified application

Species

Unspecified reactive species

Christopher J Scudder,Samantha M Mirczuk,Karen M Richardson,Victoria J Crossley,Jacob T C Regan,Ruth Gostelow,Yaiza Forcada,Katarina Hazuchova,Norelene Harrington,Imelda M McGonnell,David B Church,Patrick J Kenny,Márta Korbonits,Robert C Fowkes,Stijn J M Niessen
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