MW 162.19 Da, Purity >99%. Activator of small and intermediate conductance Ca2+ activated K+ channels (SK). Also activates apical membrane Cl- conductance CFTR channel.
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- Cell proliferation 56:e133852022Functional cooperation between IK and TRPC1 channels regulates serum-induced vascular smooth muscle cell proliferation via mediating Ca influx and ERK1/2 activation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaoling Jia,Xinlan Chen,Chao Gao,Haikun Wang,Chengxi Yang,Lin-Hua Jiang,Yubo FanPubMed 36562293
- Journal of neurophysiology 109:1514-242012Small-conductance Ca2+-activated K+ channels modulate action potential-induced Ca2+ transients in hippocampal neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRaffaella Tonini,Teresa Ferraro,Marisol Sampedro-Castañeda,Anna Cavaccini,Martin Stocker,Christopher D Richards,Paola PedarzaniPubMed 23255726
- Behavioural brain research 232:37-432012Pharmacological enhancement of calcium-activated potassium channel function reduces the effects of repeated stress on fear memory.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDerek Atchley et. al.PubMed 22487247
Key facts
- CAS number
- 10045-45-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 162.19 Da
- Molecular formula
- C9H10N2O
- PubChem identifier
- 82320
- Nature
- Synthetic
Alternative names
Apamin sensitive small conductance Ca2+ activated potassium, Apamin sensitive small conductance Ca2+ activated potassium channel, DHS2, Hsk 1, IK, IK channel, IK1, IKCa1, Intermediate conductance calcium-activated potassium channel protein 4, KCNN1_HUMAN, KCNN2_HUMAN, KCNN3_HUMAN, KCNN4_HUMAN, KCa2.1, KCa2.2, KCa2.3, KCa3.1, KCa4, Potassium calcium activated channel subfamily N member 3, Potassium calcium activated channel subfamily N member 4, Potassium channel calcium activated intermediate/small conductance subfamily N alpha member 3, Potassium channel, calcium activated, intermediate/small conductance, subfamily N, member 3, Potassium intermediate/small conductance calcium activated, Potassium intermediate/small conductance calcium activated channel subfamily N member 1, Potassium intermediate/small conductance calcium activated channel subfamily N member 2, Potassium intermediate/small conductance calcium activated channel subfamily N member 3, Potassium intermediate/small conductance calcium activated channel, subfamily N, member 4, Putative Gardos channel, SK, SK 1, SK 2, SK channel, SK3, SK4, SKCa 1, SKCa 2, SKCa 3, SKCa 4, Small conductance calcium activated potassium channel, Small conductance calcium-activated potassium channel protein 1, Small conductance calcium-activated potassium channel protein 2, Small conductance calcium-activated potassium channel protein 3, hIKCa1, hKCa4, hSK2, hSK3, hSK4
Recommended products
MW 162.19 Da, Purity >99%. Activator of small and intermediate conductance Ca2+ activated K+ channels (SK). Also activates apical membrane Cl- conductance CFTR channel.
Key facts
- CAS number
- 10045-45-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 162.19 Da
- Molecular formula
- C9H10N2O
- PubChem identifier
- 82320
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 100 mM.
- Biochemical name
- 1-Ethyl-2-benzimidazolinone
- Biological description
Activator of small and intermediate conductance Ca2+ activated K+ channels (SK). Also activates apical membrane Cl- conductance CFTR channel.
- Canonical SMILES
- CCN1C2=CC=CC=C2NC1=O
- InChI
- InChI=1S/C9H10N2O/c1-2-11-8-6-4-3-5-7(8)10-9(11)12/h3-6H,2H2,1H3,(H,10,12)
- InChIKey
- CXUCKELNYMZTRT-UHFFFAOYSA-N
- IUPAC name
- 3-ethyl-1H-benzimidazol-2-one
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
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1 product image
Chemical Structure - 1-EBIO, Activator of Ca2+-activated K+ channels and CFTR channels (ab120258)
2D chemical structure image of ab120258, 1-EBIO, Activator of Ca2+-activated K+ channels and CFTR channels
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