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AB120511

1-Phenylbiguanide, 5-HT3 receptor agonist

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(1 Publication)

MW 177.21 Da, Purity >99%. 5-HT3 receptor agonist (EC50 = 0.64 nM). Increases dopamine release. Achieve your results faster with highly validated, pure and trusted compounds.

View Alternative Names

5 HT3 D, 5 HT3 E, 5 HTR3B, 5 Hydroxytryptamine Serotonin Receptor 3a, 5 hydroxytryptamine (serotonin) receptor 3 family member D, 5 hydroxytryptamine (serotonin) receptor 3, family member C, 5 hydroxytryptamine (serotonin) receptor 3C ionotropic, 5 hydroxytryptamine 3 receptor, 5 hydroxytryptamine 3 receptor B subunit, 5 hydroxytryptamine receptor 3 subunit C, 5 hydroxytryptamine receptor 3C, 5 hydroxytryptamine receptor 3D, 5 hydroxytryptamine serotonin receptor 3B, 5-HT-3, 5-HT3 receptor subunit E splice variant HTR3Ea, 5-HT3E, 5-HT3R, 5-HT3c1, 5-hydroxytryptamine (serotonin) receptor 3 family member E, 5-hydroxytryptamine receptor 3, 5-hydroxytryptamine receptor 3 subunit D, 5-hydroxytryptamine receptor 3 subunit E, 5-hydroxytryptamine receptor 3A, 5-hydroxytryptamine receptor 3B, 5-hydroxytryptamine receptor 3E, 5HT3B_HUMAN, 5HT3E, CPC12, CPC8, CPC9, CPCJ, CYP2C, CYP2C10, HTR3, HTR3D, HTR3E, Htr3a, Htr3b, MGC119636, MGC119637, MGC120035, MGC120036, MGC120037, P450 PB 1, P450C2C, P450IIC19, P450IIC9, SEROTONIN 5-HT-3E RECEPTOR, Serotonin 5-HT-3D receptor, Serotonin gated ion channel subunit, Serotonin receptor 3B, Serotonin receptor 3C, Serotonin receptor 3D, Serotonin receptor 3E, Serotonin-gated ion channel receptor, serotonin receptor 3 subunit E

1 Images
Chemical Structure - 1-Phenylbiguanide, 5-HT3 receptor agonist (AB120511)
  • Chemical Structure

Lab

Chemical Structure - 1-Phenylbiguanide, 5-HT3 receptor agonist (AB120511)

2D chemical structure image of ab120511, 1-Phenylbiguanide, 5-HT3 receptor agonist

Key facts

CAS number

102-02-3

Purity

>99%

Form

Solid

form

Molecular weight

177.21 Da

Molecular formula

C<sub>8</sub>H<sub>1</sub><sub>1</sub>N<sub>5</sub>

PubChem

4780

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

1-Phenylbiguanide

Biological description

5-HT3 receptor agonist (EC50 = 0.64 nM). Increases dopamine release.

Canonical smiles

C1=CC=C(C=C1)N=C(N)N=C(N)N

InChi

InChI=1S/C8H11N5/c9-7(10)13-8(11)12-6-4-2-1-3-5-6/h1-5H,(H6,9,10,11,12,13)

InChiKey

CUQCMXFWIMOWRP-UHFFFAOYSA-N

IUPAC Name

1-(diaminomethylidene)-2-phenylguanidine

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The 5-HT3 receptor a serotonin receptor subtype mechanically functions as a ligand-gated ion channel. Alternate names for this receptor include 5HT3A 5HT3B HTR3C and 5HT3E. The receptor mainly consists of a pentameric structure made up of these five subunits which together allow the flow of cations across the cell membrane. The exact mass of the individual receptor subunits can vary but they roughly range between 50 and 60 kDa. The 5-HT3 receptors primarily express in the gastrointestinal tract and the central nervous system where they mediate fast excitatory synaptic transmission.
Biological function summary

The 5-HT3 receptor plays a critical role in neurotransmission and is part of a complex involved in mediating various physiological processes. It functions by binding to serotonin causing the receptor to open and allowing cation influx which depolarizes the neuron's membrane. Moreover the receptor is involved in processes like vomiting and anxiety regulation. As a member of a larger family of neurotransmitter receptors it influences how neurons communicate and ultimately impacts functions like mood and gut motility.

Pathways

5-HT3 receptors integrate into the serotonin signaling pathway which is essential in regulating mood cognition and perception. They also play a role in the emetic response pathway involving other proteins like the cytochrome P450 enzymes such as cytochrome P450 2C8 2C9 2C12 and 2C19 which are involved in drug metabolism and detoxification processes. The interaction between these pathways highlights the receptor's importance in maintaining neurotransmitter balance and drug interactions inside the body.

The 5-HT3 receptor has implications for conditions like irritable bowel syndrome (IBS) and chemotherapy-induced nausea and vomiting (CINV). Dysregulation of this receptor can lead to altered neurotransmission affecting both gastrointestinal and neurological health. In IBS abnormal receptor activity can cause disrupted gut motility while connection with cytochrome P450 enzymes influences susceptibility to CINV. The receptor's modulation provides therapeutic targets where 5-HT3 receptor antagonists and agonists like phenylbiguanide and other compounds serve as treatment options to alleviate symptoms associated with these disorders.
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in bioengineering and biotechnology 9:703241 PubMed34513812

2021

Extracellular Vesicles Derived From Human Umbilical Cord Mesenchymal Stem Cells Protect Against DOX-Induced Heart Failure Through the miR-100-5p/NOX4 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenglong Zhong,Yuqing Tian,Xiaoming Luo,Jianjie Zou,Lin Wu,Julong Tian
View all publications
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