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AB145065

10058-F4, c-Myc-Max dimerization inhibitor

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(1 Publication)

MW 249.4 Da, Purity >99%. Cell-permeable c-Myc-Max dimerization inhibitor. Downregulates c-Myc expression and upregulates CDK inhibitors, p21 and p27. Inhibits proliferation. Induces apoptosis and cell cycle arrest in G0/G1 phase. Shows antitumor effects in vivo..

View Alternative Names

ARSA_HUMAN, AS A, AW212749, Arylsulfatase A component C, As 2, C230037L18Rik, CBX, CBX1_HUMAN, Cerebroside-sulfatase, Chromobox 1, Chromobox homolog 1 (HP1 beta homolog Drosophila ), Chromobox protein homolog 1, Drosophila HP1 beta, FH, FUMH_HUMAN, Fumarase, Fumarate hydratase, Fumarate hydratase mitochondrial, HLRCC, HP1 beta, HP1 beta homolog, HP1 beta homolog Drosophila, HP1, Drosophila. homolog of, beta, HP1Hs beta, Heterochromatin protein 1 beta, Heterochromatin protein 1 homolog beta, Heterochromatin protein p25, Human heterochromatin protein p25 mRNA complete cds, LRCC, M31, MCL, MCUL 1, MGC125207, MOD 1, MS709, Modifier 1 protein, Multiple hereditary cutaneous leiomyomata, OTTHUMP00000196546, OTTHUMP00000196548, TISP73, arylsulfatase A, chromobox homolog 1, heterochromatin protein p25 beta, metachromatic leucodystrophy, p25beta

1 Images
Chemical Structure - 10058-F4, c-Myc-Max dimerization inhibitor (AB145065)
  • Chemical Structure

Lab

Chemical Structure - 10058-F4, c-Myc-Max dimerization inhibitor (AB145065)

2D chemical structure image of ab145065, 10058-F4, c-Myc-Max dimerization inhibitor

Key facts

CAS number

403811-55-2

Purity

>99%

Form

Solid

form

Molecular weight

249.4 Da

Molecular formula

C<sub>1</sub><sub>2</sub>H<sub>1</sub><sub>1</sub>NOS<sub>2</sub>

PubChem

1271002

Nature

Synthetic

Solubility

Soluble in ethanol to 25 mM

Soluble in DMSO to 100 mM

Biochemical name

5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

Biological description

Cell-permeable c-Myc-Max dimerization inhibitor. Downregulates c-Myc expression and upregulates CDK inhibitors, p21 and p27. Inhibits proliferation. Induces apoptosis and cell cycle arrest in G0/G1 phase. Shows antitumor effects in vivo.

Canonical smiles

CCC1=CC=C(C=C1)C=C2C(=O)NC(=S)S2

Isomeric smiles

CCC1=CC=C(C=C1)/C=C/2\C(=O)NC(=S)S2

InChi

InChI=1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+

InChiKey

SVXDHPADAXBMFB-JXMROGBWSA-N

IUPAC Name

(5E)-5-[(4-ethylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CBX1 also known as HP1 beta is an important component in chromatin organization and gene silencing. With a molecular weight of approximately 22 kDa CBX1 is found in the nucleus predominantly within mammalian cells. This protein is part of the heterochromatin protein 1 family playing a significant role in modulating chromatin structure by binding to histone proteins that have been methylated on lysine 9. FH or fumarase and ARSA also referred to as arylsulfatase A have different functions. Fumarase participates in the TCA cycle while ARSA plays a role in lysosomal breakdown of sulfatides.
Biological function summary

CBX1 functions as a regulator of gene expression by influencing chromatin state and forming complexes with other proteins. It associates with the methylated H3K9 histone mark essential for heterochromatin formation and transcriptional repression. FH as part of the TCA cycle facilitates the conversion of fumarate to malate while ARSA breaks down certain lipids in the lysosome. These activities of FH and ARSA are important in cellular respiration and lipid metabolism respectively allowing cells to maintain energy balance and biochemical pathways.

Pathways

CBX1 plays an important role in the epigenetic regulation pathway and is involved in DNA damage response pathways. It interacts with proteins such as SUV39H1 which is a histone methyltransferase contributing to the formation of methylated histone marks. FH is part of the metabolic TCA cycle and ARSA engages in the sphingolipid metabolism pathway. These proteins connect various steps of energy production and lipid degradation and are critical for maintaining cellular homeostasis.

CBX1 is implicated in cancer progression particularly in its alteration affecting chromatin dynamics. Mutations or dysregulation in FH are associated with hereditary leiomyomatosis and renal cell cancer (HLRCC). ARSA is linked to metachromatic leukodystrophy a disorder affecting lipid-like substances accumulation in the brain. These proteins like FH ARSA and their pathways provide potential targets for therapeutic intervention and open pathways for further research in understanding disease mechanisms.
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 43:114589 PubMed39110589

2024

Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease.

Applications

Unspecified application

Species

Unspecified reactive species

Stanley B DeVore,Matthew Schuetz,Lauren Alvey,Henry Lujan,David E Ochayon,Lindsey Williams,Wan Chi Chang,Alyssa Filuta,Brandy Ruff,Arjun Kothari,Jennifer M Hahn,Eric Brandt,Latha Satish,Krishna Roskin,Andrew B Herr,Jocelyn M Biagini,Lisa J Martin,Deniz Cagdas,Sevgi Keles,Joshua D Milner,Dorothy M Supp,Gurjit K Khurana Hershey
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