JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB144275

10Z-Hymenialdisine, pan kinase inhibitor

Be the first to review this product! Submit a review

|

(0 Publication)

MW 324.13 Da, Purity >97%. Potent pan kinase inhibitor (IC50 values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3β, Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK-γ, Cdk3/cyclin E, Erk1, PKCγ, Cdk4/cyclin D1, Cdk6/cyclin D2 and PKCα respectively). Inhibits NF-κB and IL-8 production (IC50 values are 1-2 and 0.34-0.48 μM respectively, U937 cells). Inhibits MARK2.
1 Images
Chemical Structure - 10Z-Hymenialdisine, pan kinase inhibitor (AB144275)
  • Chemical Structure

Lab

Chemical Structure - 10Z-Hymenialdisine, pan kinase inhibitor (AB144275)

2D chemical structure image of ab144275, 10Z-Hymenialdisine, pan kinase inhibitor

Key facts

Purity

>97%

Form

Solid

form

Source

Axinella carteri

Molecular weight

324.13 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>1</sub><sub>0</sub>BrN<sub>5</sub>O<sub>2</sub>

PubChem

3035462

Nature

Native

Solubility

Soluble in DMSO to 10 mM

Biochemical name

CID 3035462

Biological description

Potent pan kinase inhibitor (IC50 values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3β, Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK-γ, Cdk3/cyclin E, Erk1, PKCγ, Cdk4/cyclin D1, Cdk6/cyclin D2 and PKCα respectively). Inhibits NF-κB and IL-8 production (IC50 values are 1-2 and 0.34-0.48 μM respectively, U937 cells). Inhibits MARK2.

Canonical smiles

C1CNC(=O)C2=C(C1=C3C(=O)N=C(N3)N)C=C(N2)Br

Isomeric smiles

C\1CNC(=O)C2=C(/C1=C\3/C(=O)N=C(N3)N)C=C(N2)Br

InChi

InChI=1S/C11H10BrN5O2/c12-6-3-5-4(7-10(19)17-11(13)16-7)1-2-14-9(18)8(5)15-6/h3,15H,1-2H2,(H,14,18)(H3,13,16,17,19)/b7-4-

InChiKey

ATBAETXFFCOZOY-DAXSKMNVSA-N

IUPAC Name

(4Z)-4-(2-amino-4-oxo-1H-imidazol-5-ylidene)-2-bromo-1,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one

style
left-column

Complementary Products

Proteins & Peptides

AB119719

Recombinant Human Cyclin E1 protein

SDS-PAGE - Recombinant Human Cyclin E1 protein (AB119719)

  • 0
  • 0
Primary Antibodies

AB201008

Anti-CDK1 (phospho T161) + CDK2 / CDK3 (phospho T160) antibody [EPR19546]

RabMAb|Recombinant

Western blot - Anti-CDK1 (phospho T161) + CDK2 / CDK3 (phospho T160) antibody [EPR19546] (AB201008)

  • 0
  • 0
Primary Antibodies

AB32147

Anti-Cdk2 antibody [E304]

RabMAb|Recombinant|KO Validated

Western blot - Anti-Cdk2 antibody [E304] (AB32147)

  • 5
  • 8
Primary Antibodies

AB33911

Anti-Cyclin E1 antibody [EP435E]

BOND RX™ Validated|KO Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyclin E1 antibody [EP435E] (AB33911)

  • 4
  • 8
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com