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AB141196

1,10-Phenanthroline, Metalloprotease inhibitor

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(1 Publication)

1,10-Phenanthroline (CAS: 66-71-7)(ab141196) is a membrane permeable chelating agent and metalloprotease inhibitor. Chelates intracellular heavy metals including zinc, copper and iron. Binds DNA and modulates multiple signaling pathways in vitro and in vivo. MW 180.2, Purity >99%

- Available in different sizes to fit your experimental needs. Larger volume format available upon request
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Chemical Structure - 1,10-Phenanthroline, Metalloprotease inhibitor (AB141196)
  • Chemical Structure

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Chemical Structure - 1,10-Phenanthroline, Metalloprotease inhibitor (AB141196)

2D chemical structure image of ab141196, 1,10-Phenanthroline, Metalloprotease inhibitor

Key facts

CAS number

66-71-7

Purity

>99%

Form

Solid

form

Formulation

Constituents: 100% 1,10-Phenanthroline

Molecular weight

180.2 Da

Molecular formula

C<sub>1</sub><sub>2</sub>H<sub>8</sub>N<sub>2</sub>

PubChem

1318

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

1,10-Phenanthroline

Biological description

Membrane permeable chelating agent. Metalloprotease inhibitor. Chelates intracellular heavy metals including zinc, copper and iron. Binds DNA and modulates multiple signaling pathways in vitro and in vivo.

Canonical smiles

C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1

InChi

InChI=1S/C12H8N2/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1/h1-8H

InChiKey

DGEZNRSVGBDHLK-UHFFFAOYSA-N

IUPAC Name

1,10-phenanthroline

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full listand refine your search

Journal of the European Academy of Dermatology and Venereology : JEADV 34:558-564 PubMed31746507

2019

Significance of the angiotensin I/angiotensin II/angiotensin-(1-7) axis in the pathogenesis of systemic sclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

B Miziołek,B Bergler-Czop,E Kucharz,P Kotyla,M Kopeć-Mędrek,M Widuchowska,M Sieńczyk,L Brzezińska-Wcisło
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Product promise

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