2-(1,8-Naphthyridin-2-ly)phenol, STAT1 transcriptional activator

Key facts

CAS number

65182-56-1

Purity

>98%

Form

Solid

form

Molecular weight

222.24 Da

Molecular formula

C₁₄H₁₀N₂O

PubChem

6789423

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 25 mM

Biochemical name

CID 6789423

Biological description

Selective STAT1 transcriptional activator. No effect on unrelated transcription factors NF-κB or STAT3. Enhances ability of IFN-γ to inhibit cancer cells *in vitro*. Antitumor agent. Active *in vitro*. Cell-permeable.

Canonical smiles

C1=CC(=C2C=CC3=C(N2)N=CC=C3)C(=O)C=C1

Isomeric smiles

C1=CC(=C2C=CC3=C(N2)N=CC=C3)C(=O)C=C1

InChi

InChI=1S/C14H10N2O/c17-13-6-2-1-5-11(13)12-8-7-10-4-3-9-15-14(10)16-12/h1-9H,(H,15,16)

InChiKey

WOJJESNAZFYOMY-UHFFFAOYSA-N

IUPAC Name

6-(1H-1,8-naphthyridin-2-ylidene)cyclohexa-2,4-dien-1-one