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AB120800

2-Furoyl-LIGRLO-amide (2Fly), PAR2 agonist

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(2 Publications )

2-Furoyl-LIGRLO-amide (CAS: 729589-58-6) (ab120800) is a potent and selective PAR2 receptor agonist (EC50 = 340 nM). Induces arterial contraction. Facilitates capsaicin evoked nociception. Around 100 times more potent than SLIGR-NH2 (ab120176). MW 777.96 g/mol, Purity >95%
1 Images
Chemical Structure - 2-Furoyl-LIGRLO-amide (2Fly), PAR2 agonist (AB120800)
  • Chemical Structure

Lab

Chemical Structure - 2-Furoyl-LIGRLO-amide (2Fly), PAR2 agonist (AB120800)

2D chemical structure image of ab120800, 2-Furoyl-LIGRLO-amide (2Fly), PAR2agonist

Key facts

CAS number

729589-58-6

Purity

>95%

Form

Lyophilized

form

Molecular weight

777.96 g/mol

Nature

Synthetic

Solubility

Soluble in water to 1 mg/ml

Biological description

Potent and selective PAR2 receptor agonist (EC50 = 340 nM). Induces arterial contraction. Facilitates capsaicin evoked nociception. Around 100 times more potent than SLIGR-NH2 (ab120176).

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Complementary Products

Biochemicals

AB120176

SLIGRL-NH2, PAR2 agonist peptide

Chemical Structure - SLIGRL-NH2, PAR2 agonist peptide (AB120176)

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Biochemicals

AB120177

TFLLR-NH2, PAR1 agonist peptide

Chemical Structure - TFLLR-NH2, PAR1 agonist peptide (AB120177)

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Biochemicals

AB120498

Adenosine, Endogenous P1 receptor agonist

Chemical Structure - Adenosine, Endogenous P1 receptor agonist (AB120498)

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Biochemicals

AB285422

Sulfo-LC-SPDP

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

American journal of physiology. Lung cellular and molecular physiology 320:L845-L879 PubMed33655758

2021

PAR-2-activated secretion by airway gland serous cells: role for CFTR and inhibition by .

Applications

Unspecified application

Species

Unspecified reactive species

Derek B McMahon,Ryan M Carey,Michael A Kohanski,Nithin D Adappa,James N Palmer,Robert J Lee

The Journal of biological chemistry 295:6721-6740 PubMed32241907

2020

Polarization of protease-activated receptor 2 (PAR-2) signaling is altered during airway epithelial remodeling and deciliation.

Applications

Unspecified application

Species

Unspecified reactive species

Ryan M Carey,Jenna R Freund,Benjamin M Hariri,Nithin D Adappa,James N Palmer,Robert J Lee
View all publications
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