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AB145002

2-Hydroxypropyl-beta-cyclodextrin, modified cyclodextrin

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(1 Publication)

MW 0 g/mol, Purity >95%. Cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group. The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the HP-β-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility.

Key facts

CAS number

128446-35-5

Purity

>95%

Molecular weight

0 g/mol

Molecular formula

(C<sub>6</sub>H<sub>9</sub>O<sub>5</sub>)<sub>7</sub>(C<sub>3</sub>H<sub>7</sub>O)n

Nature

Synthetic

Solubility

Water

Biological description

Cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group. The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the HP-β-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility.

IUPAC Name

2-Hydroxypropyl-β-cyclodextrin

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biomaterials 178:373-382 PubMed29779862

2018

Replenishable drug depot to combat post-resection cancer recurrence.

Applications

Unspecified application

Species

Unspecified reactive species

Yevgeny Brudno,Matthew J Pezone,Tracy K Snyder,Oktay Uzun,Christopher T Moody,Michael Aizenberg,David J Mooney
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