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AB141523

2-Methoxyantimycin A3, Bcl-xL and Bcl-2 inhibitor

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(5 Publications)

MW 534.6 g/mol, Purity >98%. Bcl-xL and Bcl-2 inhibitor. Antiapoptotic. Depolarizes mitochrondrial membrane potential. Reduces tumor size in vivo without toxicity.
1 Images
Chemical Structure - 2-Methoxyantimycin A3, Bcl-xL and Bcl-2 inhibitor (AB141523)
  • Chemical Structure

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Chemical Structure - 2-Methoxyantimycin A3, Bcl-xL and Bcl-2 inhibitor (AB141523)

2D chemical structure image of ab141523, 2-Methoxyantimycin A3, Bcl-xL and Bcl-2 inhibitor

Key facts

Purity

>98%

Molecular weight

534.6 g/mol

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>3</sub><sub>8</sub>N<sub>2</sub>O<sub>9</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Soluble in ethanol to 10 mM

Biological description

Bcl-xL and Bcl-2 inhibitor. Antiapoptotic. Depolarizes mitochrondrial membrane potential. Reduces tumor size in vivo without toxicity.

Isomeric smiles

O=CNC1CCCC(C1OC)C(=O)N[C@@H]2C(=O)O[C@@H](C)[C@H](OC(=O)CC(C)C)[C@@H](CCCC)C(=O)O[C@@H]2C

InChi

InChI=1S/C27H38N2O9/c1-7-8-10-19-23(38-21(31)13-15(2)3)17(5)37-27(34)22(16(4)36-26(19)33)29-25(32)18-11-9-12-20(28-14-30)24(18)35-6/h9,11-12,14-17,19,22-23H,7-8,10,13H2,1-6H3,(H,28,30)(H,29,32)/t16-,17+,19-,22+,23+/m1/s1

InChiKey

CFASDUOKNNDYAT-PFQKEVSBSA-N

IUPAC Name

2-Methoxyantimycin A3

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Immunity, inflammation and disease 11:e1102 PubMed38156384

2024

PRMT5 participates in B cell overactivation in patients with primary Sjogren's syndrome (pSS) through RSAD2-mediated NF-κB signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Zhu,Jian Zheng,Yan Zhou,Tong Wu,Tiantian Zhu

Science advances 8:eabm7375 PubMed35442739

2022

Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells.

Applications

Unspecified application

Species

Unspecified reactive species

Elizabeth J Osterlund,Nehad Hirmiz,James M Pemberton,Adrien Nougarède,Qian Liu,Brian Leber,Qiyin Fang,David W Andrews

Bioengineered 13:7683-7696 PubMed35291915

2022

miRNA-93-5p in exosomes derived from M2 macrophages improves lipopolysaccharide-induced podocyte apoptosis by targeting Toll-like receptor 4.

Applications

Unspecified application

Species

Unspecified reactive species

Zhu Wang,Wansen Sun,Ruiping Li,Yan Liu

Journal of oncology 2021:2408384 PubMed34691176

2021

CircPTK2 (hsa_circ_0003221) Contributes to Laryngeal Squamous Cell Carcinoma by the miR-1278/YAP1 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhendong Yang,Jianping Jin,Tao Chang

Pharmaceutical biology 58:1229-1243 PubMed33332219

2020

Hepatoprotective effect of Xiayuxue decoction ethyl acetate fraction against carbon tetrachloride-induced liver fibrosis in mice via inducing apoptosis and suppressing activation of hepatic stellate cells.

Applications

Unspecified application

Species

Unspecified reactive species

Dingqi Zhang,Lijun Zhang,Gaofeng Chen,Ying Xu,Hailin Yang,Zhun Xiao,Jiamei Chen,Yongping Mu,Hua Zhang,Wei Liu,Ping Liu
View all publications
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