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AB120653

2-Methoxyestradiol, antitumor and antiangiogenic agent

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(1 Publication)

MW 302.41 g/mol, Purity >98%. Potent antioxidant. Inhibits angiogenesis in vivo with direct cytotoxic effects seen in vitro. Interacts with endothelial tubulin dynamics and increases the expression of death receptor 5 in endothelial cells. Induces apoptosis by p53 induction via activation of p38/JNK pathways.
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Chemical Structure - 2-Methoxyestradiol, antitumor and antiangiogenic agent (AB120653)
  • Chemical Structure

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Chemical Structure - 2-Methoxyestradiol, antitumor and antiangiogenic agent (AB120653)

2D chemical structure image of ab120653, 2-Methoxyestradiol, antitumor and antiangiogenic agent

Key facts

CAS number

362-07-2

Purity

>98%

Form

Solid

form

Molecular weight

302.41 g/mol

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>2</sub><sub>6</sub>O<sub>3</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biological description

Potent antioxidant. Inhibits angiogenesis in vivo with direct cytotoxic effects seen in vitro. Interacts with endothelial tubulin dynamics and increases the expression of death receptor 5 in endothelial cells. Induces apoptosis by p53 induction via activation of p38/JNK pathways.

IUPAC Name

(17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Immunity 50:600-615.e15 PubMed30824325

2019

CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Liu,Xiaomin Zhang,Kun Chen,Yujie Cheng,Shuxun Liu,Meng Xia,Yali Chen,Ha Zhu,Zhiqing Li,Xuetao Cao
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