JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB285374

2-Nitro-5-thiothiocyanatobenzoic acid

Be the first to review this product! Submit a review

|

(1 Publication)

MW 224.2 Da, Purity >97%. Used to cyanylate proteins and to specifically cleave the amino-terminal peptide bond of cysteine residues. Also acts as an hydratase inhibitor.

Key facts

CAS number

30211-77-9

Purity

>97%

Form

Solid

form

Molecular weight

224.2 Da

Molecular formula

C<sub>8</sub>H<sub>4</sub>N<sub>2</sub>O<sub>4</sub>S

PubChem

92266

Nature

Synthetic

Solubility

DMSO (>10 mg/ml)

Ethanol (>20 mg/ml)

Biochemical name

2-Nitro-5-thiocyanatobenzoic acid

Biological description

Used to cyanylate proteins and to specifically cleave the amino-terminal peptide bond of cysteine residues. Also acts as an hydratase inhibitor.

Canonical smiles

C1=CC(=C(C=C1SC#N)C(=O)O)[N+](=O)[O-]

InChi

InChI=1S/C8H4N2O4S/c9-4-15-5-1-2-7(10(13)14)6(3-5)8(11)12/h1-3H,(H,11,12)

InChiKey

NQUNIMFHIWQQGJ-UHFFFAOYSA-N

IUPAC Name

2-nitro-5-thiocyanatobenzoic acid

style
left-column

Complementary Products

Proteins & Peptides

AB316446

Recombinant Human Mucin 5AC Protein Standard (His tag)

Sandwich ELISA - Recombinant Human Mucin 5AC Protein Standard (His tag) (AB316446)

  • 0
  • 0
Primary Antibodies

AB3649

Anti-Mucin 5AC antibody [45M1]

BOND RX™ Validated|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mucin 5AC antibody [45M1] (AB3649)

  • 5
  • 8
Primary Antibodies

AB77995

Anti-MUC5B antibody [19.4E]

Immunohistochemistry (Frozen sections) - Anti-MUC5B antibody [19.4E] (AB77995)

  • 5
  • 2
Primary Antibodies

AB179509

Anti-beta IV Tubulin antibody [EPR16776]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-beta IV Tubulin antibody [EPR16776] (AB179509)

  • 5
  • 1
style
left-column

Product details

This product is manufactured by BioVision, an Abcam company and was previously called B1316 2-Nitro-5-thiothiocyanatobenzoic acid. B1316-50 is the same size as the 50 mg size of ab285374.

Protect from air and light.

style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

|

Refer to SDS for further information.

style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Science translational medicine 8:363ra150 PubMed27807285

2016

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients.

Applications

Unspecified application

Species

Unspecified reactive species

Matthew E Kennedy,Andrew W Stamford,Xia Chen,Kathleen Cox,Jared N Cumming,Marissa F Dockendorf,Michael Egan,Larry Ereshefsky,Robert A Hodgson,Lynn A Hyde,Stanford Jhee,Huub J Kleijn,Reshma Kuvelkar,Wei Li,Britta A Mattson,Hong Mei,John Palcza,Jack D Scott,Michael Tanen,Matthew D Troyer,Jack L Tseng,Julie A Stone,Eric M Parker,Mark S Forman
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com