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AB146146

20(S)-Hydroxycholesterol, Smoothened activator

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MW 402.65 g/mol. Allosteric activator of the Hedgehog (Hh) signaling pathway Smoothened (Smo) oncoprotein. Binds at a site distinct from the canonical cyclopamine binding site. Activates Hh signaling (EC50 = ~ 3 μM for induction of Hh reporter gene transcription in NIH 3T3 cells). Also exhibits osteogenic activity and activates the liver X receptor (LXR).
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Chemical Structure - 20(S)-Hydroxycholesterol, Smoothened activator (AB146146)
  • Chemical Structure

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Chemical Structure - 20(S)-Hydroxycholesterol, Smoothened activator (AB146146)

2D chemical structure image of ab146146, 20(S)-Hydroxycholesterol, Smoothened activator

Key facts

CAS number

516-72-3

Molecular weight

402.65 g/mol

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>4</sub><sub>6</sub>O<sub>2</sub>

Nature

Synthetic

Biological description

Allosteric activator of the Hedgehog (Hh) signaling pathway Smoothened (Smo) oncoprotein. Binds at a site distinct from the canonical cyclopamine binding site. Activates Hh signaling (EC50 = ~ 3 μM for induction of Hh reporter gene transcription in NIH 3T3 cells). Also exhibits osteogenic activity and activates the liver X receptor (LXR).

Isomeric smiles

CC(C)CCC[C@@](C)(O)[C@H]4CC[C@@H]3[C@]4(C)CC[C@H]2[C@H]3CC=C1C[C@@H](O)CC[C@@]12C

InChi

InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27+/m0/s1

InChiKey

MCKLJFJEQRYRQT-MGNSQDQZSA-N

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Biochemicals

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25-Hydroxycholesterol, cholesterol metabolite

Chemical Structure - 25-Hydroxycholesterol, cholesterol metabolite (AB146145)

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Biochemicals

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Biochemicals

AB146144

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Chemical Structure - 7alpha-Hydroxycholesterol, Bile acid precursor (AB146144)

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Biochemicals

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HPI-1, hedgehog signaling inhibitor

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