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AB120616

2,3-Butanedione 2-monoxime (BDM), Non-selective myosin ATPase inhibitor

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(3 Publications)

MW 101.1 g/mol. Non-selective myosin ATPase inhibitor (Ki = 5 mM at myosin II). Potent Kv2.1 (DRK1) and L-Type Ca2+ channel inhibitor (Ki and IC50 values are 10.7 nM and 5.8 mM, respectively). Blood-brain barrier permeable. Inhibits muscle contraction.
1 Images
Chemical Structure - 2,3-Butanedione 2-monoxime (BDM), Non-selective myosin ATPase inhibitor (AB120616)
  • Chemical Structure

Lab

Chemical Structure - 2,3-Butanedione 2-monoxime (BDM), Non-selective myosin ATPase inhibitor (AB120616)

2D chemical structure image of ab120616, 2,3-Butanedione 2-monoxime (BDM), Non-selective myosin ATPase inhibitor

Key facts

CAS number

57-71-6

Form

Solid

form

Molecular weight

101.1 g/mol

Molecular formula

C<sub>4</sub>H<sub>7</sub>NO<sub>2</sub>

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biological description

Non-selective myosin ATPase inhibitor (Ki = 5 mM at myosin II). Potent Kv2.1 (DRK1) and L-Type Ca2+ channel inhibitor (Ki and IC50 values are 10.7 nM and 5.8 mM, respectively). Blood-brain barrier permeable. Inhibits muscle contraction.

IUPAC Name

2,3-Butanedione monoxime

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

American journal of physiology. Regulatory, integrative and comparative physiology 323:R616-R627 PubMed36094447

2022

K4 channels in isolectin B4 muscle dorsal root ganglion neurons of rats with experimental peripheral artery disease: effects of bradykinin B1 and B2 receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Qin Li,Lu Qin,Jianhua Li

eLife 11: PubMed35373735

2022

Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction.

Applications

Unspecified application

Species

Unspecified reactive species

Alex Cornean,Jakob Gierten,Bettina Welz,Juan Luis Mateo,Thomas Thumberger,Joachim Wittbrodt

Cell systems 12:670-687.e10 PubMed34043964

2021

Cell states beyond transcriptomics: Integrating structural organization and gene expression in hiPSC-derived cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Kaytlyn A Gerbin,Tanya Grancharova,Rory M Donovan-Maiye,Melissa C Hendershott,Helen G Anderson,Jackson M Brown,Jianxu Chen,Stephanie Q Dinh,Jamie L Gehring,Gregory R Johnson,HyeonWoo Lee,Aditya Nath,Angelique M Nelson,M Filip Sluzewski,Matheus P Viana,Calysta Yan,Rebecca J Zaunbrecher,Kimberly R Cordes Metzler,Nathalie Gaudreault,Theo A Knijnenburg,Susanne M Rafelski,Julie A Theriot,Ruwanthi N Gunawardane
View all publications
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