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AB120841

3-Methyladenine, selective PI3K inhibitor

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(5 Publications)

MW 149.15 g/mol, Purity >98%. Selective PI3K inhibitor. Inhibits the initial phase of the autophagy. Blocks autophagosome formation. Potentiates apoptosis. Inhibits protein degradation (IC50 = 5 mM, rat hepatocytes).
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Chemical Structure - 3-Methyladenine, selective PI3K inhibitor (AB120841)
  • Chemical Structure

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Chemical Structure - 3-Methyladenine, selective PI3K inhibitor (AB120841)

2D chemical structure image of ab120841, 3-Methyladenine, selective PI3K inhibitor

Key facts

CAS number

5142-23-4

Purity

>98%

Form

Solid

form

Molecular weight

149.15 g/mol

Molecular formula

C<sub>6</sub>H<sub>7</sub>N<sub>5</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biological description

Selective PI3K inhibitor. Inhibits the initial phase of the autophagy. Blocks autophagosome formation. Potentiates apoptosis. Inhibits protein degradation (IC50 = 5 mM, rat hepatocytes).

Canonical smiles

NC=2N=CN(C)C1=NC=NC1=2

InChi

InChI=1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3

InChiKey

FSASIHFSFGAIJM-UHFFFAOYSA-N

IUPAC Name

3-Methyl-3H-purin-6-amine

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Nutrients 15: PubMed37630743

2023

Diosgenin Targets CaMKK2 to Alleviate Type II Diabetic Nephropathy through Improving Autophagy, Mitophagy and Mitochondrial Dynamics.

Applications

Unspecified application

Species

Unspecified reactive species

Yujie Zhong,Ruyi Jin,Ruilin Luo,Jiayu Liu,Luting Ren,Yinghan Zhang,Zhongguo Shan,Xiaoli Peng

Journal of cellular physiology 238:2135-2146 PubMed37565586

2023

Matrix stiffness regulates neovascular homeostasis through autophagy in nude mice.

Applications

Unspecified application

Species

Unspecified reactive species

Bingqing Wang,Yuqing Yang,Yichen Wang,Yanxin Yang,Yi Li,Chenxi Hu,Changyue Xue

International journal of molecular sciences 21: PubMed32466385

2020

Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Claudia Espinosa-Garcia,Fahim Atif,Seema Yousuf,Iqbal Sayeed,Gretchen N Neigh,Donald G Stein

Biochemical and biophysical research communication 514:1185-1191 PubMed31103260

2019

The N-terminal sequence of murine PRMT5 variant 2 is required for Hsp70 interaction and CHIP ligase-mediated degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Weizhe Lu,Jun-Dal Kim,Saori Tabara,Chulwon Kwon,Hayase Mizukami,Keiji Kimura,Akiyoshi Fukamizu

Nature communications 10:1973 PubMed31036822

2019

A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Qiyao Chai,Xudong Wang,Lihua Qiang,Yong Zhang,Pupu Ge,Zhe Lu,Yanzhao Zhong,Bingxi Li,Jing Wang,Lingqiang Zhang,Dawang Zhou,Wei Li,Wenzhu Dong,Yu Pang,George Fu Gao,Cui Hua Liu
View all publications
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