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AB145589

3-Nitropropionic acid, Succinic dehydrogenase (complex II) inhibitor

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MW 119.08 Da, Purity >97%. Selective, irreversible succinic dehydrogenase (complex II) inhibitor. Induces mitochondrial citric acid cycle dysfunction, oxidative stress and cell death. Activates the Keap1-Nrf2-ARE pathway. Inhibits the MAPK and NF-κB pathways. Shows neurotoxic effects in vivo. .
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Chemical Structure - 3-Nitropropionic acid, Succinic dehydrogenase (complex II) inhibitor (AB145589)
  • Chemical Structure

Lab

Chemical Structure - 3-Nitropropionic acid, Succinic dehydrogenase (complex II) inhibitor (AB145589)

2D chemical structure image of ab145589, 3-Nitropropionic acid, Succinic dehydrogenase (complex II) inhibitor

Key facts

CAS number

504-88-1

Purity

>97%

Form

Solid

form

Molecular weight

119.08 Da

Molecular formula

C<sub>3</sub>H<sub>5</sub>NO<sub>4</sub>

PubChem

1678

Nature

Synthetic

Solubility

Soluble in ethanol to 100 mM

Biochemical name

3-Nitropropionic acid

Biological description

Selective, irreversible succinic dehydrogenase (complex II) inhibitor. Induces mitochondrial citric acid cycle dysfunction, oxidative stress and cell death. Activates the Keap1-Nrf2-ARE pathway. Inhibits the MAPK and NF-κB pathways. Shows neurotoxic effects in vivo.

Canonical smiles

C(C[N+](=O)[O-])C(=O)O

InChi

InChI=1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)

InChiKey

WBLZUCOIBUDNBV-UHFFFAOYSA-N

IUPAC Name

3-nitropropanoic acid

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Complementary Products

Primary Antibodies

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Biochemicals

AB223880

TTFA, Mitochondrial Complex II inhibitor

Chemical Structure - TTFA, Mitochondrial Complex II inhibitor (AB223880)

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Primary Antibodies

AB224639

Anti-CD40 antibody [EPR20735]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-CD40 antibody [EPR20735] (AB224639)

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Assay Kits

AB83431

Alpha Ketoglutarate (alpha KG) Assay Kit

Functional Studies - Alpha Ketoglutarate (alpha KG) Assay Kit (AB83431)

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2093 3-Nitropropionic acid. 2093-250 is the same size as the 250 mg size of ab145589.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Product promise

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