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AB120122

4-Aminopyridine (4-AP), K+ channel blocker

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(14 Publications)

MW 94.11 Da, Purity >99%. Potassium channel blocker. Blocks Kv channels. Convulsant, and useful tool to model epileptiform activity *in vitro*.

View Alternative Names

ATFB7, Cyclic GMP gated potassium channel, HK 2, HPCN1, Hck 1, Inward rectifier K(+) channel Kir7.1, Inward rectifier potassium channel 13, KCA10_HUMAN, KCJ13_HUMAN, KCNA 10, KCNA5_HUMAN, KCNB2_HUMAN, KCND1_HUMAN, KCNJ13, KIR1.4, KIR7.1, KV1.5, Kcn 1, Kv1.8, Kv4.1, LCA16, OTTHUMP00000025805, OTTHUMP00000025806, PCN1, Potassium channel, Potassium channel, insulinoma and islet cell, Potassium channel, voltage-gated, shaker-related subfamily, member 5, Potassium inwardly rectifying channel subfamily J member 13, Potassium voltage gated channel Shal related subfamily member 1, Potassium voltage gated channel shaker related subfamily member 10, Potassium voltage-gated channel subfamily A member 10, Potassium voltage-gated channel subfamily A member 5, Potassium voltage-gated channel subfamily B member 2, Potassium voltage-gated channel subfamily D member 1, SVD, Shal type potassium channel, Voltage gated potassium channel Kv4.1, Voltage-gated potassium channel HK2, Voltage-gated potassium channel subunit Kv1.5, Voltage-gated potassium channel subunit Kv1.8, Voltage-gated potassium channel subunit Kv2.2, Voltage-gated potassium channel subunit Kv4.1, cardiac potassium channel, delayed rectifier potassium channel protein, insulinoma and islet potassium channel, inwardly rectifying subfamily J member 13, mShal, potassium channel 1, potassium channel Kv2.2, voltage-gated potassium channel protein Kv1.5

2 Images
Immunocytochemistry/ Immunofluorescence - 4-Aminopyridine (4-AP), K+ channel blocker (AB120122)
  • ICC/IF

PubMed

Immunocytochemistry/ Immunofluorescence - 4-Aminopyridine (4-AP), K+ channel blocker (AB120122)

4-AP-induced LFPs provoke AP firing from SST-interneurons. Representative images of GCaMP3 signal in a visual field containing several SST interneurons before (left) and during (right) LFPP-CA3/DG (induced with 4-AP).

Grosser S et al., PloS one., 9(1) : e86250. Fig 3A.; doi : 10.1371/journal.pone.0086250

Image from Grosser S et al., PloS one., 9(1): e86250. Fig 3A.; doi: 10.1371/journal.pone.0086250 Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

Chemical Structure - 4-Aminopyridine (4-AP), K+ channel blocker (AB120122)
  • Chemical Structure

Lab

Chemical Structure - 4-Aminopyridine (4-AP), K+ channel blocker (AB120122)

2D chemical structure image of ab120122, 4-Aminopyridine (4-AP), K+ channel blocker

Key facts

CAS number

504-24-5

Purity

>99%

Form

Solid

form

Molecular weight

94.11 Da

Molecular formula

C<sub>5</sub>H<sub>6</sub>N<sub>2</sub>

PubChem

1727

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

4-Aminopyridine

Biological description

Potassium channel blocker. Blocks Kv channels. Convulsant, and useful tool to model epileptiform activity *in vitro*.

Canonical smiles

C1=CN=CC=C1N

InChi

InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)

InChiKey

NUKYPUAOHBNCPY-UHFFFAOYSA-N

IUPAC Name

pyridin-4-amine

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Kv2.2 also known as KCNB2 KCNA10 KCNA5/KV1-5 and Kir7.1/KCNJ13 are voltage-gated potassium channels. Mechanically these channels mediate the flow of potassium ions across the cell membrane important for cellular excitability. Kv2.2 in particular has a molecular mass of about 104 kDa. It is widely expressed in various tissues including the brain and heart where it plays a significant role in repolarization of the action potential and in modulating electrical signaling in neurons and cardiac cells.
Biological function summary

Kv2.2 and its related family members influence the physiological functions of cells by stabilizing resting membrane potential and regulating neurotransmitter release. Kv2.2 channels are often part of larger channel complexes interacting with other proteins to form functional units that respond to changes in membrane potential. These channels significantly affect cellular excitability and signal propagation and are sensitive to pharmacological agents like 4-aminopyridine a known blocker of potassium channels.

Pathways

Kv2.2 channels participate in critical signaling pathways such as those related to neurotransmission and cardiac rhythm maintenance. The MAPK pathway is one area where Kv2.2 functions integrating signals that modulate cell activity. Related proteins include KCNA1 and KCNQ2 which share roles in maintaining electrical gradients and facilitating rapid signaling across excitable membranes.

Kv2.2 channels have been implicated in conditions such as epilepsy and cardiac arrhythmias. Disruption in Kv2.2 function can lead to abnormal neuronal firing contributing to epileptic seizures. Similarly in cardiac tissues dysfunctions in these channels may result in arrhythmias. The Kv1.1 and Kv3.1 proteins are related to these disorders through their shared responsibility in regulating electrical activity highlighting the importance of potassium channels in normal physiology and pathophysiology.
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Product protocols

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Publications (14)

Recent publications for all applications. Explore the full list and refine your search

Neuron 111:2899-2917.e6 PubMed37442130

2023

Toggling between food-seeking and self-preservation behaviors via hypothalamic response networks.

Applications

Unspecified application

Species

Unspecified reactive species

Isabel de Araujo Salgado,Chia Li,C Joseph Burnett,Shakira Rodriguez Gonzalez,Jordan J Becker,Allison Horvath,Thomas Earnest,Alexxai V Kravitz,Michael J Krashes

Acta pharmacologica Sinica 44:1600-1611 PubMed36973542

2023

(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Wang,Xiao-Yun Qiu,Jia-Ying Liu,Bei Tan,Fei Wang,Min-Juan Sun,Xu-Hong Jiang,Xu-Ming Ji,Ceng-Lin Xu,Yi Wang,Zhong Chen

Neuron 110:3036-3052.e5 PubMed35944526

2022

Control of fear by discrete prefrontal GABAergic populations encoding valence-specific information.

Applications

Unspecified application

Species

Unspecified reactive species

Kirstie A Cummings,Sabina Bayshtok,Tri N Dong,Paul J Kenny,Roger L Clem

Neuron 109:1365-1380.e5 PubMed33740416

2021

Periaqueductal gray/dorsal raphe dopamine neurons contribute to sex differences in pain-related behaviors.

Applications

Unspecified application

Species

Unspecified reactive species

Waylin Yu,Dipanwita Pati,Melanie M Pina,Karl T Schmidt,Kristen M Boyt,Avery C Hunker,Larry S Zweifel,Zoe A McElligott,Thomas L Kash

Nature 538:383-387 PubMed27732573

2016

Cortico-fugal output from visual cortex promotes plasticity of innate motor behaviour.

Applications

Unspecified application

Species

Unspecified reactive species

Bao-Hua Liu,Andrew D Huberman,Massimo Scanziani

The Journal of neuroscience : the official journal of the Society for Neuroscience 34:15601-9 PubMed25411488

2014

Pathway-selective adjustment of prefrontal-amygdala transmission during fear encoding.

Applications

Unspecified application

Species

Unspecified reactive species

Maithe Arruda-Carvalho,Roger L Clem

Frontiers in cellular neuroscience 8:155 PubMed24936172

2014

The inflammatory molecules IL-1β and HMGB1 can rapidly enhance focal seizure generation in a brain slice model of temporal lobe epilepsy.

Applications

Unspecified application

Species

Unspecified reactive species

Angela Chiavegato,Emanuele Zurolo,Gabriele Losi,Eleonora Aronica,Giorgio Carmignoto

PloS one 9:e86250 PubMed24465989

2014

Hilar somatostatin interneurons contribute to synchronized GABA activity in an in vitro epilepsy model.

Applications

Unspecified application

Species

Unspecified reactive species

Sabine Grosser,Bridget N Queenan,Rupa R Lalchandani,Stefano Vicini

The Journal of physiology 591:807-22 PubMed23207591

2012

Fast spiking interneuron control of seizure propagation in a cortical slice model of focal epilepsy.

Applications

Unspecified application

Species

Unspecified reactive species

Mario Cammarota,Gabriele Losi,Angela Chiavegato,Micaela Zonta,Giorgio Carmignoto

Proceedings of the National Academy of Sciences of 109:20720-5 PubMed23185019

2012

Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation.

Applications

Unspecified application

Species

Unspecified reactive species

Takuya Sasaki,Kaoru Beppu,Kenji F Tanaka,Yugo Fukazawa,Ryuichi Shigemoto,Ko Matsui
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