JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB141502

4-Hydroxynonenal, Lipid peroxidation marker

Be the first to review this product! Submit a review

|

(5 Publications)

MW 156.22 Da, Purity >97%. Marker of lipid peroxidation. Prevents NF-κB activation and TNF expression by inhibiting IκB phosphorylation. Range of biological effects such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. Active in vivo.
2 Images
Functional Studies - 4-Hydroxynonenal, Lipid peroxidation marker (AB141502)
  • FuncS

PubMed

Functional Studies - 4-Hydroxynonenal, Lipid peroxidation marker (AB141502)

Western blot results of biomarkers of protein synthesis, proteolysis and oxidative stress in the diaphragm.

Panel B) The levels of 4-hydroxynonenal (4- HNE) were analyzed as an indicator of lipid peroxidation via Western blotting. A representative blot for 4-HNE protein conjugates is shown above the graph (Con n = 8, CMV n = 7, Ext 12 n = 8, Ext24 n = 8). C/D) Calpain (C) (Con n = 6, CMV n = 7, Ext 12 n = 7, Ext24 n = 8) and caspase-3.

Bruells et al PLoS One. 2014 Jan 27;9(1):e87460. doi: 10.1371/journal.pone.0087460. eCollection 2014. Fig 3. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

Chemical Structure - 4-Hydroxynonenal, Lipid peroxidation marker (AB141502)
  • Chemical Structure

Lab

Chemical Structure - 4-Hydroxynonenal, Lipid peroxidation marker (AB141502)

2D chemical structure image of ab141502, 4-Hydroxynonenal, Lipid peroxidation marker

Key facts

CAS number

75899-68-2

Purity

>97%

Form

Liquid

form

Molecular weight

156.22 Da

Molecular formula

C<sub>9</sub>H<sub>1</sub><sub>6</sub>O<sub>2</sub>

PubChem

5283344

Nature

Synthetic

Biochemical name

4-Hydroxynonenal

Biological description

Marker of lipid peroxidation. Prevents NF-κB activation and TNF expression by inhibiting IκB phosphorylation. Range of biological effects such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. Active in vivo.

Canonical smiles

CCCCCC(C=CC=O)O

Isomeric smiles

CCCCCC(/C=C/C=O)O

InChi

InChI=1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+

InChiKey

JVJFIQYAHPMBBX-FNORWQNLSA-N

IUPAC Name

(E)-4-hydroxynon-2-enal

style
left-column

Complementary Products

Assay Kits

AB118970

Lipid Peroxidation (MDA) Assay Kit (Colorimetric/Fluorometric)

Biochemical assay - Lipid Peroxidation (MDA) Assay Kit (Colorimetric/Fluorometric) (AB118970)

  • 5
  • 3
Primary Antibodies

AB181602

Anti-GAPDH antibody [EPR16891] - Loading Control

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAPDH antibody [EPR16891] - Loading Control (AB181602)

  • 5
  • 23
Primary Antibodies

AB46545

Anti-4 Hydroxynonenal antibody

Western blot - Anti-4 Hydroxynonenal antibody (AB46545)

  • 4
  • 27
Primary Antibodies

AB48506

Anti-4 Hydroxynonenal antibody [HNEJ-2]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-4 Hydroxynonenal antibody [HNEJ-2] (AB48506)

  • 4
  • 10
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

|

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

|

Refer to SDS for further information.

style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Redox biology 76:103318 PubMed39178733

2024

ALDH2 deficiency augments atherosclerosis through the USP14-cGAS-dependent polarization of proinflammatory macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Haiying Rui,Huaxiang Yu,Kai Chi,Ziqi Han,Wenyong Zhu,Jian Zhang,Haipeng Guo,Wenyi Zou,Fengxin Wang,Ping Xu,Dan Zou,Xiaoshuai Song,Lulu Liu,Xuting Wu,Wenxiao Wu,Dandan Qin,Yihai Cao,Feng Xu,Li Xue,Yuguo Chen

Pharmacological research 157:104851 PubMed32423865

2020

Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Ilari,Luigino Antonio Giancotti,Filomena Lauro,Concetta Dagostino,Micaela Gliozzi,Valentina Malafoglia,Luigi Sansone,Ernesto Palma,Marco Tafani,Matteo Antonio Russo,Carlo Tomino,Massimo Fini,Daniela Salvemini,Vincenzo Mollace,Carolina Muscoli

Biochemical and biophysical research communications 522:518-524 PubMed31784085

2019

A small-molecule activator of mitochondrial aldehyde dehydrogenase 2 reduces the severity of cerulein-induced acute pancreatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Shengchuan Cao,Yuan Bian,Xin Zhou,Qiuhuan Yuan,Shujian Wei,Li Xue,Feihong Yang, Qianqian Dong, Wenjun Wang,Boyuan Zheng,Jian Zhang,Zheng Wang,Ziqi Han,Kehui Yang,Haiying Rui,Ying Zhang,Feng Xu,Yuguo Chen

Journal of neurochemistry 144:710-722 PubMed29238976

2018

A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Naoko Niimi,Hideji Yako,Shizuka Takaku,Hiroshi Kato,Takafumi Matsumoto,Yasumasa Nishito,Kazuhiko Watabe,Saori Ogasawara,Hiroki Mizukami,Soroku Yagihashi,Sookja K Chung,Kazunori Sango

PloS one 9:e87460 PubMed24475293

2014

Recovery of diaphragm function following mechanical ventilation in a rodent model.

Applications

Unspecified application

Species

Unspecified reactive species

Christian S Bruells,Ingmar Bergs,Rolf Rossaint,Jun Du,Christian Bleilevens,Andreas Goetzenich,Joachim Weis,Michael P Wiggs,Scott K Powers,Marc Hein
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com