MW 228.21 Da, Purity >99%. Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC50 = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro. Active in vivo.
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- Oncoimmunology 12:22677442023() promoter hypomethylation predicts immunotherapy response in metastatic urothelial carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNiklas Klümper,Lennert Wüst,Jonas Saal,Damian J Ralser,Romina Zarbl,Jonas Jarczyk,Johannes Breyer,Danijel Sikic,Bernd Wullich,Christian Bolenz,Florian Roghmann,Michael Hölzel,Manuel Ritter,Sebastian Strieth,Arndt Hartmann,Philipp Erben,Ralph M Wirtz,Jennifer Landsberg,Dimo Dietrich,Markus EcksteinPubMed 37868689
- Clinical epigenetics 15:1122023CTLA4 DNA methylation is associated with CTLA-4 expression and predicts response to immunotherapy in head and neck squamous cell carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFriederike Hoffmann,Alina Franzen,Luka de Vos,Lennert Wuest,Zsófi Kulcsár,Simon Fietz,Alexander Philippe Maas,Sarah Hollick,Marie Yatou Diop,Jennis Gabrielpillai,Timo Vogt,Pia Kuster,Romina Zarbl,Joern Dietrich,Glen Kristiansen,Peter Brossart,Jennifer Landsberg,Sebastian Strieth,Dimo DietrichPubMed 37415208
- Life science alliance 6:2023Time-resolved proteomic analyses of senescence highlight metabolic rewiring of mitochondria.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJun Yong Kim,Ilian Atanassov,Frederik Dethloff,Lara Kroczek,Thomas LangerPubMed 37321846
- Biomarker research 11:562023ICOS DNA methylation regulates melanoma cell-intrinsic ICOS expression, is associated with melanoma differentiation, prognosis, and predicts response to immune checkpoint blockade.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDamian J Ralser,Emmanuelle Herr,Luka de Vos,Zsófi Kulcsár,Romina Zarbl,Niklas Klümper,Gerrit H Gielen,Alexander Philippe Maas,Friederike Hoffmann,Jörn Dietrich,Pia Kuster,Alexander Mustea,Nicole Glodde,Glen Kristiansen,Sebastian Strieth,Jennifer Landsberg,Dimo DietrichPubMed 37259155
- Clinical epigenetics 14:502022DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunotherapy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDennis Niebel,Anne Fröhlich,Romina Zarbl,Simon Fietz,Luka de Vos,Timo J Vogt,Jörn Dietrich,Judith Sirokay,Pia Kuster,Gonzalo Saavedra,Susana Ramírez Valladolid,Friederike Hoffmann,Sebastian Strieth,Jennifer Landsberg,Dimo DietrichPubMed 35410311
- British journal of cancer 125:865-8762021SLC38A4 functions as a tumour suppressor in hepatocellular carcinoma through modulating Wnt/β-catenin/MYC/HMGCS2 axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJie Li,Ming-Han Li,Tian-Tian Wang,Xiao-Ning Liu,Xiao-Ting Zhu,Yun-Zhang Dai,Ke-Chao Zhai,Yong-da Liu,Jia-Li Lin,Rui-Liang Ge,Shu-Han Sun,Fang Wang,Ji-Hang YuanPubMed 34274945
- Journal of virology 93:2019Human Papillomavirus 16 E2 Regulates Keratinocyte Gene Expression Relevant to Cancer and the Viral Life Cycle.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMichael R Evans et. al.PubMed 30518656
- Cellular physiology and biochemistry : internation 50:1815-18312018Secreted Frizzled Related Protein 2 Modulates Epithelial-Mesenchymal Transition and Stemness via Wnt/β-Catenin Signaling in Choriocarcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXianling Zeng et. al.PubMed 30396168
- British journal of cancer 120:115-1272018VISTA expressed in tumour cells regulates T cell function.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKumuluzi Mulati,Junzo Hamanishi,Noriomi Matsumura,Kenji Chamoto,Nathan Mise,Kaoru Abiko,Tsukasa Baba,Ken Yamaguchi,Naoki Horikawa,Ryusuke Murakami,Mana Taki,Kharma Budiman,Xiang Zeng,Yuko Hosoe,Miyuki Azuma,Ikuo Konishi,Masaki MandaiPubMed 30382166
- Leukemia 33:905-9172018Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDonia M Moujalled,Giovanna Pomilio,Corina Ghiurau,Adam Ivey,Jessica Salmon,Sewa Rijal,Sarah Macraild,Lan Zhang,Tse-Chieh Teh,Ing-Soo Tiong,Ping Lan,Maia Chanrion,Audrey Claperon,Francesca Rocchetti,Adrien Zichi,Laurence Kraus-Berthier,Youzhen Wang,Ensar Halilovic,Erick Morris,Frédéric Colland,David Segal,David Huang,Andrew W Roberts,Ana Leticia Maragno,Guillaume Lessene,Olivier Geneste,Andrew H WeiPubMed 30214012
Key facts
- CAS number
2353-33-5
- Purity
> 99%
- Form
Solid
- Molecular weight
228.21 Da
- Molecular formula
C8H12N4O4
- PubChem identifier
451668
- Nature
Synthetic
Target data
Recommended products
MW 228.21 Da, Purity >99%. Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC50 = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro. Active in vivo.
Key facts
- CAS number
2353-33-5
- Purity
> 99%
- Form
Solid
- Molecular weight
228.21 Da
- Molecular formula
C8H12N4O4
- PubChem identifier
451668
- Nature
Synthetic
- Solubility
Soluble in water to 50 mM. Soluble in DMSO to 50 mM.
- Biochemical name
Decitabine
- Biological description
Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC50 = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro. Active in vivo.
- Canonical SMILES
C1C(C(OC1N2C=NC(=NC2=O)N)CO)O
- Isomeric SMILES
C1[C@@H]([C@H](O[C@H]1N2C=NC(=NC2=O)N)CO)O
- InChI
InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
- InChIKey
XAUDJQYHKZQPEU-KVQBGUIXSA-N
- IUPAC name
4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
+4°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
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1 product image
Chemical Structure - 5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor (ab120842)
2D chemical structure image of ab120842, 5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor
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