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AB120842

5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor

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(11 Publications)

MW 228.21 Da, Purity >99%. Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC50 = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro. Active in vivo.
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Chemical Structure - 5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor (AB120842)
  • Chemical Structure

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Chemical Structure - 5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor (AB120842)

2D chemical structure image of ab120842, 5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor

Key facts

CAS number

2353-33-5

Purity

>99%

Form

Solid

form

Molecular weight

228.21 Da

Molecular formula

C<sub>8</sub>H<sub>1</sub><sub>2</sub>N<sub>4</sub>O<sub>4</sub>

PubChem

451668

Nature

Synthetic

Solubility

Soluble in water to 50 mM

Soluble in DMSO to 50 mM

Biochemical name

Decitabine

Biological description

Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC50 = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro. Active in vivo.

Canonical smiles

C1C(C(OC1N2C=NC(=NC2=O)N)CO)O

Isomeric smiles

C1[C@@H]([C@H](O[C@H]1N2C=NC(=NC2=O)N)CO)O

InChi

InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1

InChiKey

XAUDJQYHKZQPEU-KVQBGUIXSA-N

IUPAC Name

4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

Oncoimmunology 12:2267744 PubMed37868689

2023

() promoter hypomethylation predicts immunotherapy response in metastatic urothelial carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Niklas Klümper,Lennert Wüst,Jonas Saal,Damian J Ralser,Romina Zarbl,Jonas Jarczyk,Johannes Breyer,Danijel Sikic,Bernd Wullich,Christian Bolenz,Florian Roghmann,Michael Hölzel,Manuel Ritter,Sebastian Strieth,Arndt Hartmann,Philipp Erben,Ralph M Wirtz,Jennifer Landsberg,Dimo Dietrich,Markus Eckstein

Epigenetics 18:2239607 PubMed37523636

2023

Oncogenic DNA methyltransferase 1 activates the PI3K/AKT/mTOR signalling by blocking the binding of HSPB8 and BAG3 in melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yemei Yang,Shengfang Ma,Zi Ye,Yushi Zheng,Zhenjiong Zheng,Xiongshan Liu,Xianyi Zhou

Clinical epigenetics 15:112 PubMed37415208

2023

CTLA4 DNA methylation is associated with CTLA-4 expression and predicts response to immunotherapy in head and neck squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Friederike Hoffmann,Alina Franzen,Luka de Vos,Lennert Wuest,Zsófi Kulcsár,Simon Fietz,Alexander Philippe Maas,Sarah Hollick,Marie Yatou Diop,Jennis Gabrielpillai,Timo Vogt,Pia Kuster,Romina Zarbl,Joern Dietrich,Glen Kristiansen,Peter Brossart,Jennifer Landsberg,Sebastian Strieth,Dimo Dietrich

Life science alliance 6: PubMed37321846

2023

Time-resolved proteomic analyses of senescence highlight metabolic rewiring of mitochondria.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Yong Kim,Ilian Atanassov,Frederik Dethloff,Lara Kroczek,Thomas Langer

Biomarker research 11:56 PubMed37259155

2023

ICOS DNA methylation regulates melanoma cell-intrinsic ICOS expression, is associated with melanoma differentiation, prognosis, and predicts response to immune checkpoint blockade.

Applications

Unspecified application

Species

Unspecified reactive species

Damian J Ralser,Emmanuelle Herr,Luka de Vos,Zsófi Kulcsár,Romina Zarbl,Niklas Klümper,Gerrit H Gielen,Alexander Philippe Maas,Friederike Hoffmann,Jörn Dietrich,Pia Kuster,Alexander Mustea,Nicole Glodde,Glen Kristiansen,Sebastian Strieth,Jennifer Landsberg,Dimo Dietrich

Clinical epigenetics 14:50 PubMed35410311

2022

DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Dennis Niebel,Anne Fröhlich,Romina Zarbl,Simon Fietz,Luka de Vos,Timo J Vogt,Jörn Dietrich,Judith Sirokay,Pia Kuster,Gonzalo Saavedra,Susana Ramírez Valladolid,Friederike Hoffmann,Sebastian Strieth,Jennifer Landsberg,Dimo Dietrich

British journal of cancer 125:865-876 PubMed34274945

2021

SLC38A4 functions as a tumour suppressor in hepatocellular carcinoma through modulating Wnt/β-catenin/MYC/HMGCS2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Li,Ming-Han Li,Tian-Tian Wang,Xiao-Ning Liu,Xiao-Ting Zhu,Yun-Zhang Dai,Ke-Chao Zhai,Yong-da Liu,Jia-Li Lin,Rui-Liang Ge,Shu-Han Sun,Fang Wang,Ji-Hang Yuan

Journal of virology 93: PubMed30518656

2019

Human Papillomavirus 16 E2 Regulates Keratinocyte Gene Expression Relevant to Cancer and the Viral Life Cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Michael R Evans,Claire D James,Molly L Bristol,Tara J Nulton,Xu Wang,Namsimar Kaur,Elizabeth A White,Brad Windle,Iain M Morgan

Cellular physiology and biochemistry : internation 50:1815-1831 PubMed30396168

2018

Secreted Frizzled Related Protein 2 Modulates Epithelial-Mesenchymal Transition and Stemness via Wnt/β-Catenin Signaling in Choriocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xianling Zeng,Yafei Zhang,Huiqiu Xu,Taohong Zhang,Yan Xue,Ruifang An

British journal of cancer 120:115-127 PubMed30382166

2018

VISTA expressed in tumour cells regulates T cell function.

Applications

Unspecified application

Species

Unspecified reactive species

Kumuluzi Mulati,Junzo Hamanishi,Noriomi Matsumura,Kenji Chamoto,Nathan Mise,Kaoru Abiko,Tsukasa Baba,Ken Yamaguchi,Naoki Horikawa,Ryusuke Murakami,Mana Taki,Kharma Budiman,Xiang Zeng,Yuko Hosoe,Miyuki Azuma,Ikuo Konishi,Masaki Mandai
View all publications
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We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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