5-Azacytidine, DNMT1 inhibitor

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(11 Publications)

MW 244.2 Da, Purity >98%. Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC₅₀ = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows anti-metabolic and anti-cancer activities in vitro. Active in vivo. At high doses the compound can have effects on other DNA methyltransferases.

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ADCADN, AIM, AIS, ANDR_HUMAN, AR, AR8, ATAD5_HUMAN, ATPase family AAA domain containing 5, ATPase family AAA domain-containing protein 5, Aging-associated gene 9 protein, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Apoptosis associated protein, Beta globin chain, Beta-globin, C17orf41, CD113t C, CXXC finger protein 9, CXXC-type zinc finger protein 9, CXXC9, Chromosome fragility-associated gene 1 protein, Cytosolic NADP-isocitrate dehydrogenase, DHTR, DNA (cytosine-5)-methyltransferase 1, DNA MTase, DNA MTase HsaI, DNA methyltransferase 1, DNA methyltransferase HsaI, DNA methyltransferase M.HsaI., DNMT, DNMT1_HUMAN, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), Dnmt1o, ELG1, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ESRL 1, ESRR A, Enhanced level of genomic instability 1 homolog, Epididymis luminal protein 216, Epididymis secretory protein Li 26, Epididymis secretory sperm binding protein Li 162eP, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, FLJ16293, FRAG1, G3PD, G3PDH, G3P_HUMAN, GAPD, GAPDH, GCCR, GCRST, GCR_HUMAN, GR, Glucocorticoid receptor, Glyceraldehyde-3-phosphate dehydrogenase, Grl1, Growth arrest and DNA damage inducible 34, Growth arrest and DNA damage-inducible protein GADD34, HBB_HUMAN, HEL-216, HEL-S-162eP, HEL-S-26, HSN1E, HUMARA, HYSP1, Hemoglobin beta, Hemoglobin beta chain, Hemoglobin subunit beta, ICDH, IDCD, IDH, IDH1, IDHC_HUMAN, IDP, IDPC, IMD42, Isocitrate dehydrogenase (NADP(+)) 1 cytosolic, Isocitrate dehydrogenase 1 (NADP+) soluble, Isocitrate dehydrogenase [NADP] cytoplasmic, KD, Kennedy disease (KD), LVV-hemorphin-7, M.HsaI, MCMT, MGC104992, MGC129539, Met1, MommeD2, Myeloid differentiation primary response protein MyD116 homolog, NADP dependent isocitrate dehydrogenase cytosolic, NADP dependent isocitrate dehydrogenase peroxisomal, NADP(+)-specific ICDH, NF-E2-related factor 2, NF2L2_HUMAN, NR1F3, NR3B1, NR3C4, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Oxalosuccinate decarboxylase, PICD, PR15A_HUMAN, Peptidyl-cysteine S-nitrosylase GAPDH, Ppp1r15a, Protein phosphatase 1 regulatory (inhibitor) subunit 15A, Protein phosphatase 1 regulatory subunit 15A, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RORG_HUMAN, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, SBMA, SMAX1, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid hormone receptor ERR1, TFM, TOR, Testicular Feminization (TFM), androgen receptor splice variant 4b, chromosome fragility associated gene 1, erythroid derived 2, estrogen receptor related receptor alpha, glucocorticoid nuclear receptor variant 1, hERR1, like 2, mMmul, nr3c1, nuclear factor erythroid 2 like 2, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)