5-Fluorocytosine (5-FC), antifungal agent

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Interferon gamma (IFN-γ) MCL1 Caspase-1 and the Androgen Receptor (AR) are essential proteins with distinct mechanical roles in biological systems. Interferon gamma recognized for its mass of about 20 kDa primarily derives from immune cells like T lymphocytes and natural killer cells. MCL1 belongs to the BCL-2 family and functions as an anti-apoptotic protein mainly found in the mitochondria. Caspase-1 with a mass of approximately 45 kDa acts as an inflammatory enzyme cleaving precursors of interleukin-1 into their active forms and is expressed predominantly in macrophages. The Androgen Receptor is a nuclear receptor transcription factor found in a variety of tissues including prostate and skeletal muscle with a mass of about 110 kDa.

Biological function summary

These proteins play unique functions collaborating within various cellular processes. Interferon gamma guides the immune response influencing antimicrobial and antiviral defenses and modulating cell-mediated immunity. MCL1 supports cell survival preventing apoptosis by binding to and neutralizing pro-apoptotic factors. Caspase-1 is an integral component of the inflammasome complex facilitating the secretion of pro-inflammatory cytokines. The Androgen Receptor modulates gene expression upon binding with androgens impacting growth and differentiation especially in male reproductive tissues.

Pathways

IFN-γ engages in Jak-STAT signaling interacting with proteins such as JAK1 and STAT1 that propagate immune response signals. MCL1 plays a vital role in the intrinsic apoptotic pathway associated with proteins like BAX and BAK. Caspase-1 participates in the inflammatory pathways notably interacting with NLRP3 (NOD-like receptor family pyrin domain containing 3) controlling inflammatory processes. The Androgen Receptor significantly contributes to the androgen signaling pathway linked with proteins like coactivators and corepressors that regulate gene transcription.

Associated diseases and disorders

Interferon gamma has associations with autoimmune conditions including rheumatoid arthritis often in conjunction with TNF-alpha. MCL1 dysregulation frequently appears in cancers such as leukemia where it interacts with other BCL-2 family proteins to promote cell survival. Caspase-1 connects to inflammatory disorders including inflammatory bowel disease through its interaction with proteins like IL-1β influencing chronic inflammation. The Androgen Receptor links to prostate cancer where its altered signaling contributes to tumor development and progression often recognizing key proteins in the prostate cancer signaling pathway.