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AB142387

5-Fluorouracil, RNA and DNA synthesis inhibitor

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(2 Publications)

MW 135.07 Da, Purity >98%. RNA and DNA synthesis inhibitor. Anticancer agent. Pyrimidine analog causing misincorporation of fluoronucleotides into DNA/RNA during synthesis. Thymidylate synthase inhibitor. Induces cell cycle arrest G1/S and apoptosis. Orally active.
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Chemical Structure - 5-Fluorouracil, RNA and DNA synthesis inhibitor (AB142387)
  • Chemical Structure

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Chemical Structure - 5-Fluorouracil, RNA and DNA synthesis inhibitor (AB142387)

2D chemical structure image of ab142387, 5-Fluorouracil, RNA and DNA synthesis inhibitor

Key facts

CAS number

1189492-99-6

Purity

>98%

Form

Solid

form

Molecular weight

135.07 Da

Molecular formula

C<sub>4</sub>H<sub>5</sub>FN<sub>2</sub>O<sub>2</sub>

PubChem

45039276

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

5-Fluorodihydropyrimidine-2,4-dione-13C,15N2

Biological description

RNA and DNA synthesis inhibitor. Anticancer agent. Pyrimidine analog causing misincorporation of fluoronucleotides into DNA/RNA during synthesis. Thymidylate synthase inhibitor. Induces cell cycle arrest G1/S and apoptosis. Orally active.

Canonical smiles

C1C(C(=O)NC(=O)N1)F

Isomeric smiles

C1C(C(=O)[15NH][13C](=O)[15NH]1)F

InChi

InChI=1S/C4H5FN2O2/c5-2-1-6-4(9)7-3(2)8/h2H,1H2,(H2,6,7,8,9)/i4+1,6+1,7+1

InChiKey

RAIRJKWTBBDDAR-XZQGXACKSA-N

IUPAC Name

5-fluoro-(213C,1,3-15N2)1,3-diazinane-2,4-dione

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Primary Antibodies

AB81299

Anti-gamma H2A.X (phospho S139) antibody [EP854(2)Y]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-gamma H2A.X (phospho S139) antibody [EP854(2)Y] (AB81299)

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  • 17
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Human molecular genetics 32:1826-1835 PubMed36715159

2023

Accelerated epigenetic aging and DNA methylation alterations in Berardinelli-Seip congenital lipodystrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Abeer Qannan,Yosra Bejaoui,Mahmoud Izadi,Noha A Yousri,Aleem Razzaq,Colette Christiansen,George M Martin,Jordana T Bell,Steve Horvath,Junko Oshima,Andre Megarbane,Johan Ericsson,Ehsan Pourkarimi,Nady El Hajj

Emerging microbes & infections 6:e24 PubMed28442752

2017

Zika virus infection reprograms global transcription of host cells to allow sustained infection.

Applications

Unspecified application

Species

Unspecified reactive species

Shashi Kant Tiwari,Jason Dang,Yue Qin,Gianluigi Lichinchi,Vikas Bansal,Tariq M Rana
View all publications
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