MW 135.07 Da, Purity >98%. RNA and DNA synthesis inhibitor. Anticancer agent. Pyrimidine analog causing misincorporation of fluoronucleotides into DNA/RNA during synthesis. Thymidylate synthase inhibitor. Induces cell cycle arrest G1/S and apoptosis. Orally active.
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- Human molecular genetics 32:1826-18352023Accelerated epigenetic aging and DNA methylation alterations in Berardinelli-Seip congenital lipodystrophy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAbeer Qannan,Yosra Bejaoui,Mahmoud Izadi,Noha A Yousri,Aleem Razzaq,Colette Christiansen,George M Martin,Jordana T Bell,Steve Horvath,Junko Oshima,Andre Megarbane,Johan Ericsson,Ehsan Pourkarimi,Nady El HajjPubMed 36715159
- Emerging microbes & infections 6:e242017Zika virus infection reprograms global transcription of host cells to allow sustained infection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShashi Kant Tiwari,Jason Dang,Yue Qin,Gianluigi Lichinchi,Vikas Bansal,Tariq M RanaPubMed 28442752
Key facts
- CAS number
- 1189492-99-6
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 135.07 Da
- Molecular formula
- C4H5FN2O2
- PubChem identifier
- 45039276
- Nature
- Synthetic
Recommended products
MW 135.07 Da, Purity >98%. RNA and DNA synthesis inhibitor. Anticancer agent. Pyrimidine analog causing misincorporation of fluoronucleotides into DNA/RNA during synthesis. Thymidylate synthase inhibitor. Induces cell cycle arrest G1/S and apoptosis. Orally active.
Key facts
- CAS number
- 1189492-99-6
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 135.07 Da
- Molecular formula
- C4H5FN2O2
- PubChem identifier
- 45039276
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
- 5-Fluorodihydropyrimidine-2,4-dione-13C,15N2
- Biological description
RNA and DNA synthesis inhibitor. Anticancer agent. Pyrimidine analog causing misincorporation of fluoronucleotides into DNA/RNA during synthesis. Thymidylate synthase inhibitor. Induces cell cycle arrest G1/S and apoptosis. Orally active.
- Canonical SMILES
- C1C(C(=O)NC(=O)N1)F
- Isomeric SMILES
- C1C(C(=O)[15NH][13C](=O)[15NH]1)F
- InChI
- InChI=1S/C4H5FN2O2/c5-2-1-6-4(9)7-3(2)8/h2H,1H2,(H2,6,7,8,9)/i4+1,6+1,7+1
- InChIKey
- RAIRJKWTBBDDAR-XZQGXACKSA-N
- IUPAC name
- 5-fluoro-(213C,1,3-15N2)1,3-diazinane-2,4-dione
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
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1 product image
Chemical Structure - 5-Fluorouracil, RNA and DNA synthesis inhibitor (ab142387)
2D chemical structure image of ab142387, 5-Fluorouracil, RNA and DNA synthesis inhibitor
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