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AB145291

5(6)-CFDA N-succinimidyl ester (CFSE), Fluorogenic esterase substrate

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(3 Publications)

MW 557.46 g/mol, Purity >90%. Cell-permeable, fluorogenic, non-selective esterase substrate. Hydrolyzes to hydrophilic fluorescent 5(6)-CFDA (ab145278) and 5(6)-FAM (ab145342) derivatives intracellularly. Partitions with high fidelity between daughter cells for up to eight generational divisions. Tracks cell proliferation.

Key facts

CAS number

150347-59-4

Purity

>90%

Form

Powder

form

Molecular weight

557.46 g/mol

Molecular formula

C<sub>2</sub><sub>9</sub>H<sub>1</sub><sub>9</sub>NO<sub>1</sub><sub>1</sub>

Nature

Synthetic

Solubility

Soluble in DMSO

Biological description

Cell-permeable, fluorogenic, non-selective esterase substrate. Hydrolyzes to hydrophilic fluorescent 5(6)-CFDA (ab145278) and 5(6)-FAM (ab145342) derivatives intracellularly. Partitions with high fidelity between daughter cells for up to eight generational divisions. Tracks cell proliferation.

InChi

InChI=1S/C24H16O7.C6H7NO4/c1-13(25)28-15-7-9-19-21(11-15)30-22-12-16(29-14(2)26)8-10-20(22)24(19)18-6-4-3-5-17(18)23(27)31-24;1-4(8)11-7-5(9)2-3-6(7)10/h3-12H,1-2H3;2-3H2,1H3

InChiKey

KQPBJOQXHVRGEG-UHFFFAOYSA-N

IUPAC Name

5(6)-Carboxyfluorescein diacetate N-succinimidyl ester

Excitation/Emission

Ex: 495nm, Em: 520nm

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Complementary Products

Assay Kits

AB187965

Live Cell Staining Kit - Red Fluorescence (Ex/Em = 646/ 660 nm)

Immunocytochemistry/ Immunofluorescence - Live Cell Staining Kit - Red Fluorescence (Ex/Em = 646/ 660 nm) (AB187965)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Reagents, Controls & Accessories

AB113853

CFSE - Cell Labeling Kit

Flow Cytometry - CFSE - Cell Labeling Kit (AB113853)

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Primary Antibodies

AB206278

Alexa Fluor® 647 Anti-Actin antibody [EPR16769] - Cytoskeleton Marker

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-Actin antibody [EPR16769] - Cytoskeleton Marker (AB206278)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Breast cancer (Tokyo, Japan) 32:988-1005 PubMed40411659

2025

Helix pomatia agglutinin bound to surface glycans of small extracellular vesicles in-vitro and in-vivo increases in early and late stage breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jamie Cooper,Bethy Airstone,Ellie Beaman,Emanuela Carollo,Susan Ann Brooks,Ryan Charles Pink

EMBO molecular medicine 16:416-428 PubMed38225455

2024

Bacteria colonization in tumor microenvironment creates a favorable niche for immunogenic chemotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

See-Khai Lim,Wen-Ching Lin,Sin-Wei Huang,Yi-Chung Pan,Che-Wei Hu,Chung-Yuan Mou,Che-Ming Jack Hu,Kurt Yun Mou

PloS one 15:e0244160 PubMed33370374

2020

Transplantation of chicken egg white extract-induced rabbit PBMCs as a treatment for renal ischemia-reperfusion injury in rabbits.

Applications

Unspecified application

Species

Unspecified reactive species

Guang-Ping Ruan,Xiang Yao,Qing-Keng Lin,Zi-An Li,Xue-Min Cai,Rong-Qing Pang,Xing-Hua Pan
View all publications
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