MW 284.3 Da, Purity >95%. High affinity aryl hydrocarbon receptor ligand. Proposed endogenous AhR ligand.
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- Leukemia & lymphoma 60:1697-17082018Retinoic acid and 6-formylindolo(3,2-b)carbazole (FICZ) combination therapy reveals putative targets for enhancing response in non-APL AML.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRodica P Bunaciu,Robert J MacDonald,Holly A Jensen,Feng Gao,Xin Wang,Lynn Johnson,Jeffrey D Varner,Andrew YenPubMed 30570341
- PloS one 10:e013566820156-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRodica P Bunaciu et. al.PubMed 26287494
Key facts
- CAS number
- 172922-91-7
- Purity
- > 95%
- Form
- Solid
- Molecular weight
- 284.3 Da
- Molecular formula
- C19H12N2O
- PubChem identifier
- 1863
- Nature
- Synthetic
Recommended products
MW 284.3 Da, Purity >95%. High affinity aryl hydrocarbon receptor ligand. Proposed endogenous AhR ligand.
Key facts
- CAS number
- 172922-91-7
- Purity
- > 95%
- Form
- Solid
- Molecular weight
- 284.3 Da
- Molecular formula
- C19H12N2O
- PubChem identifier
- 1863
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 25 mM.
- Biochemical name
- 5,11-Dihydroindolo[3,2-b]carbazole-6-carbaldehyde
- Biological description
High affinity aryl hydrocarbon receptor ligand. Proposed endogenous AhR ligand.
- Canonical SMILES
- C1=CC=C2C(=C1)C3=CC4=C(C5=CC=CC=C5N4)C(=C3N2)C=O
- InChI
- InChI=1S/C19H12N2O/c22-10-14-18-12-6-2-4-8-16(12)20-17(18)9-13-11-5-1-3-7-15(11)21-19(13)14/h1-10,20-21H
- InChIKey
- ZUDXFBWDXVNRKF-UHFFFAOYSA-N
- IUPAC name
- 5,11-dihydroindolo[3,2-b]carbazole-12-carbaldehyde
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - 6-Formylindolo(3,2-b)carbazole, Aryl hydrocarbon receptor ligand (ab141631)
2D chemical structure image of ab141631, 6-Formylindolo(3,2-b)carbazole, Aryl hydrocarbon receptor ligand
Bunaciu et al PLoS One. 2015; 10(8): e0135668. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Functional Studies - 6-Formylindolo(3,2-b)carbazole, Aryl hydrocarbon receptor ligand (ab141631)
FICZ upregulates Cyp1A1 expression.HL-60 cells were initiated in culture at 0.1 x 106 cells/ml with 1 μM RA, 100 nM FICZ, 1 μM α-NF as indicated for 2 h and 48 h. At 2 h post treatment, FICZ upregulates Cyp1A1 expression in HL-60 cells, reaching significance for RA+FICZ vs C (p = 0.0029) and vs RA (p = 0.0045) and α-NF+FICZ+RA vs C (p = 0.0086) and vs RA (p = 0.0134).
FICZ = 6-Formylindolo(3,2-b)carbazole, Aryl hydrocarbon receptor ligand.
(From Figure 4 of Bunaciu et al).
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