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MW 1270.4 Da, Purity >98%. Fluorescent DNA dye for apoptosis and flow cytometry studies. Guanine-specific synthetic fluorescent analogue of actinomycin D. Intercalates DNA by binding to GC regions. Discriminates between live cells as well as early and late apoptosis in flow cytometry. Excitation/emission = 488/647 nm.

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Images

Chemical Structure - 7-Aminoactinomycin D (7-AAD), Fluorescent DNA dye (AB142391), expandable thumbnail

Publications

Key facts

CAS number
7240-37-1
Purity
> 98%
Form
Solid
Molecular weight
1270.4 Da
Molecular formula
C62H87N13O16
PubChem identifier
65180
Nature
Synthetic

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MW 1270.4 Da, Purity >98%. Fluorescent DNA dye for apoptosis and flow cytometry studies. Guanine-specific synthetic fluorescent analogue of actinomycin D. Intercalates DNA by binding to GC regions. Discriminates between live cells as well as early and late apoptosis in flow cytometry. Excitation/emission = 488/647 nm.

Key facts

Purity
> 98%
PubChem identifier
65180
Solubility

Soluble in DMSO to 10 mM.

Biochemical name
CID 65180
Biological description

Fluorescent DNA dye for apoptosis and flow cytometry studies. Guanine-specific synthetic fluorescent analogue of actinomycin D. Intercalates DNA by binding to GC regions. Discriminates between live cells as well as early and late apoptosis in flow cytometry. Excitation/emission = 488/647 nm.

Canonical SMILES
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=CC(=C(C4=C3N=C5C(=C(C(=O)C(=C5O4)C)N)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)C)N
InChI
InChI=1S/C62H87N13O16/c1-26(2)42-59(85)74-21-17-19-36(74)57(83)70(13)24-38(76)72(15)48(28(5)6)61(87)89-32(11)44(55(81)66-42)68-53(79)34-23-35(63)30(9)51-46(34)65-47-40(41(64)50(78)31(10)52(47)91-51)54(80)69-45-33(12)90-62(88)49(29(7)8)73(16)39(77)25-71(14)58(84)37-20-18-22-75(37)60(86)43(27(3)4)67-56(45)82/h23,26-29,32-33,36-37,42-45,48-49H,17-22,24-25,63-64H2,1-16H3,(H,66,81)(H,67,82)(H,68,79)(H,69,80)
InChIKey
YXHLJMWYDTXDHS-UHFFFAOYSA-N
IUPAC name
2,7-diamino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - 7-Aminoactinomycin D (7-AAD), Fluorescent DNA dye (ab142391), expandable thumbnail

    Chemical Structure - 7-Aminoactinomycin D (7-AAD), Fluorescent DNA dye (ab142391)

    2D chemical structure image of ab142391, 7-Aminoactinomycin D (7-AAD), Fluorescent DNA dye

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Product protocols

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