8-Br-cGMP (8-Bromo-cGMP), PKG activator

Key facts

CAS number

51116-01-9

Purity

>95%

Form

Solid

form

Molecular weight

446.08 Da

Molecular formula

C₁₀H₁₀BrN₅NaO₇P

PubChem

44134592

Nature

Synthetic

Solubility

Soluble in water to 50 mM

Biochemical name

CID 44134592

Biological description

Cell permeable cGMP analog. PKG activator. Increases Ca²⁺ levels and active in vivo.

Canonical smiles

C1C2C(C(C(O2)N3C4=C(C(=O)N=C(N4)N)N=C3Br)O)OP(=O)(O1)[O-].[Na+]

Isomeric smiles

C1C2C(C(C(O2)N3C4=C(C(=O)N=C(N4)N)N=C3Br)O)OP(=O)(O1)[O-].[Na+]

InChi

InChI=1S/C10H11BrN5O7P.Na/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(22-8)1-21-24(19,20)23-5;/h2,4-5,8,17H,1H2,(H,19,20)(H3,12,14,15,18);/q;+1/p-1

InChiKey

ZJRFCXHKYQVNFK-UHFFFAOYSA-M

IUPAC Name

sodium;2-amino-8-bromo-9-(7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-3H-purin-6-one