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MW 283.24 Da, Purity >98%. Oxidative stress biomarker. A predominant form of free radical-induced oxidative lesions in nuclear and mitochondrial DNA. Oxidized deoxyguanosine derivative. Biomarker for oxidative stress and carcinogenesis.

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Images

Chemical Structure - 8-Hydroxy-2'-deoxyguanosine, Oxidative stress biomarker (AB145595), expandable thumbnail
  • Functional Studies - 8-Hydroxy-2'-deoxyguanosine, Oxidative stress biomarker (AB145595), expandable thumbnail

Publications

Key facts

Purity
> 98%
Form
Solid
Molecular weight
283.24 Da
Molecular formula
C10H13N5O5
PubChem identifier
73318
Nature
Synthetic

Target data

Recommended products

MW 283.24 Da, Purity >98%. Oxidative stress biomarker. A predominant form of free radical-induced oxidative lesions in nuclear and mitochondrial DNA. Oxidized deoxyguanosine derivative. Biomarker for oxidative stress and carcinogenesis.

Key facts

Purity
> 98%
PubChem identifier
73318
Solubility

Soluble in DMSO to 25 mM.

Biochemical name
CID 73318
Biological description

Oxidative stress biomarker. A predominant form of free radical-induced oxidative lesions in nuclear and mitochondrial DNA. Oxidized deoxyguanosine derivative. Biomarker for oxidative stress and carcinogenesis.

Canonical SMILES
C1C(C(OC1N2C3=C(C(=O)N=C(N3)N)NC2=O)CO)O
Isomeric SMILES
C1[C@@H]([C@H](O[C@H]1N2C3=C(C(=O)N=C(N3)N)NC2=O)CO)O
InChI
InChI=1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1
InChIKey
HCAJQHYUCKICQH-VPENINKCSA-N
IUPAC name
2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 2177 8-Hydroxy-2'-deoxyguanosine. 2177-5 is the same size as the 5 mg size of ab145595.

Product promise

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2 product images

  • Chemical Structure - 8-Hydroxy-2'-deoxyguanosine, Oxidative stress biomarker (ab145595), expandable thumbnail

    Chemical Structure - 8-Hydroxy-2'-deoxyguanosine, Oxidative stress biomarker (ab145595)

    2D chemical structure image of ab145595, 8-Hydroxy-2'-deoxyguanosine, Oxidative stress biomarker

  • Functional Studies - 8-Hydroxy-2'-deoxyguanosine, Oxidative stress biomarker (ab145595), expandable thumbnail
    Zhang et al PLoS One. 2014 Aug 27;9(8):e105994. doi: 10.1371/journal.pone.0105994. eCollection 2014. Fig 4. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

    Functional Studies - 8-Hydroxy-2'-deoxyguanosine, Oxidative stress biomarker (ab145595)

    Pimonidazole staining and 8-Hydroxy-2'-deoxyguanosine expression in xenograft tumors.

    A, Hypoxia was detected in 2 mm (a), 5 mm (b), 10 mm (c) and 15 mm (d) tumors by pimonidazole staining.

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Product protocols

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