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AB145594

8-Hydroxyguanosine, biomarker for oxidative damage

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(1 Publication)

MW 299.24 Da, Purity >98%. Biomarker for oxidative damage to nucleic acids and lipids. Product of oxidative damage of RNA. Promotes differentiation and shows antiproliferative effects.
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Chemical Structure - 8-Hydroxyguanosine, biomarker for oxidative damage (AB145594)
  • Chemical Structure

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Chemical Structure - 8-Hydroxyguanosine, biomarker for oxidative damage (AB145594)

2D chemical structure image of ab145594, 8-Hydroxyguanosine, biomarker for oxidative damage

Key facts

CAS number

3868-31-3

Purity

>98%

Form

Solid

form

Molecular weight

299.24 Da

Molecular formula

C<sub>1</sub><sub>0</sub>H<sub>1</sub><sub>3</sub>N<sub>5</sub>O<sub>6</sub>

PubChem

65131

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biochemical name

CID 65131

Biological description

Biomarker for oxidative damage to nucleic acids and lipids. Product of oxidative damage of RNA. Promotes differentiation and shows antiproliferative effects.

Canonical smiles

C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)NC2=O)O)O)O

Isomeric smiles

C([C@@H]1[C@H]([C@H]([C@@H](O1)N2C3=C(C(=O)N=C(N3)N)NC2=O)O)O)O

InChi

InChI=1S/C10H13N5O6/c11-9-13-6-3(7(19)14-9)12-10(20)15(6)8-5(18)4(17)2(1-16)21-8/h2,4-5,8,16-18H,1H2,(H,12,20)(H3,11,13,14,19)/t2-,4-,5-,8-/m1/s1

InChiKey

FPGSEBKFEJEOSA-UMMCILCDSA-N

IUPAC Name

2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2176 8-Hydroxyguanosine. 2176-5 is the same size as the 5 mg size of ab145594.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 11:6339 PubMed33311482

2020

Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Enyong Dai,Leng Han,Jiao Liu,Yangchun Xie,Herbert J Zeh,Rui Kang,Lulu Bai,Daolin Tang
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Complementary Products

Primary Antibodies

AB48508

Anti-8-Hydroxy-2'-deoxyguanosine antibody [N45.1]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-8-Hydroxy-2'-deoxyguanosine antibody [N45.1] (AB48508)

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Biochemicals

AB145595

8-Hydroxy-2'-deoxyguanosine, Oxidative stress biomarker

Chemical Structure - 8-Hydroxy-2'-deoxyguanosine, Oxidative stress biomarker (AB145595)

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Primary Antibodies

AB62623

Anti-DNA/RNA Damage antibody [15A3]

Immunocytochemistry - Anti-DNA/RNA Damage antibody [15A3] (AB62623)

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Primary Antibodies

AB61392

Anti-3-Nitrotyrosine antibody [39B6]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-3-Nitrotyrosine antibody [39B6] (AB61392)

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