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MW 300.4 Da, Purity >98%. High affinity, endogenous retinoic acid receptor (RAR) agonist (IC50= 14 nM for RARα, RARβ and RARγ). Active metabolite of vitamin A. Acts as a transcription factor to regulate the growth and differentiation of normal and malignant cells and capable of inhibiting prostaglandin-endoperoxide synthase 2 expression.
Alternative names=Atherosclerosis, susceptibility to, included, DAUD I6, DKFZp686N23123, ER, ER-alpha, ER-beta, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESTR B, Early response protein NAK1, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen resistance, included, FLJ00280, FLJ00318, FLJ16020, FLJ16733, GFRP 1, Growth Factor Inducible Nuclear Protein NP10, Growth Factor Response Protein 1, Growth factor inducible nuclear protein N10, H 2RIIBP, HAP, HBV-activated protein, HDL cholesterol, augmented response of, to hormone replacement, included, HMR, Hbr1, Hormone Receptor, LX receptor beta, LXR a, LXR b, LXR beta, Liver X nuclear receptor beta, Liver X receptor alpha, Liver X receptor beta, MGC102720, MGC109416, MGC1831, MGC9485, MHC class I promoter binding protein, Myocardial infarction, susceptibility to, included, N10, N10 nuclear protein, NAK 1, NER I, NER1, NGFIB, NP 10, NR1B1, NR1B2, NR1B3, NR1H2_HUMAN, NR1H3_HUMAN, NR2B1, NR2B2, NR2B3, NR3A1, NR3A2, NR4A1_HUMAN, NUR77, mouse, homolog of, Nerve growth factor IB nuclear receptor variant 1, Nuclear Hormone Receptor TR3, Nuclear hormone receptor NUR/77, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear orphan receptor LXR beta, Nuclear receptor NER, Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 1 group B member 2, Nuclear receptor subfamily 1 group B member 3, Nuclear receptor subfamily 1 group H member 2, Nuclear receptor subfamily 1 group H member 3, Nuclear receptor subfamily 2 group B member 1, Nuclear receptor subfamily 2 group B member 2, Nuclear receptor subfamily 2 group B member 3, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 4 group A member 1, Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, OR-1, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000022510, OTTHUMP00000060418, Orphan nuclear receptor HMR, Orphan nuclear receptor NR4A1, Orphan nuclear receptor TR3, Orphan receptor tr3, Oxysterols receptor LXR-alpha, Oxysterols receptor LXR-beta, RAR, RAR-alpha, RAR-beta, RAR-epsilon, RAR-gamma, RARA_HUMAN, RARB_HUMAN, RARC, RARG_HUMAN, RARalpha1, RIP15, RLD 1, RNESTROR, RRB2, RXR alpha1, RXR beta, RXR gamma, RXRA_HUMAN, RXRB_HUMAN, RXRC, RXRG_HUMAN, Receptor NGFIB, Retanoic X receptor gamma, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor RXR-alpha, Retinoic acid receptor RXR-beta, Retinoic acid receptor RXR-gamma, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, Retinoic acid receptor beta, Retinoic acid receptor beta 2, Retinoic acid receptor beta 4, Retinoic acid receptor beta 5, Retinoic acid receptor beta polypeptide, Retinoic acid receptor gamma 2, Retinoic acid receptor, gamma, Retinoid X nuclear receptor alpha, Retinoid X receptor alpha, Retinoid X receptor beta, Retinoid X receptor gamma, ST-59, Steroid hormone nuclear receptor NER, Steroid receptor TR3, TR 3, TR3 orphan receptor, Testicular receptor 3, UNR, Ubiquitously-expressed nuclear receptor
- CAS number
5300-03-8
- Purity
> 98%
- Form
Solid
- Molecular weight
300.4 Da
- Molecular formula
C20H28O2
- PubChem identifier
449171
- Nature
Synthetic
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MW 300.4 Da, Purity >98%. High affinity, endogenous retinoic acid receptor (RAR) agonist (IC50= 14 nM for RARα, RARβ and RARγ). Active metabolite of vitamin A. Acts as a transcription factor to regulate the growth and differentiation of normal and malignant cells and capable of inhibiting prostaglandin-endoperoxide synthase 2 expression.
Alternative names=Atherosclerosis, susceptibility to, included, DAUD I6, DKFZp686N23123, ER, ER-alpha, ER-beta, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESTR B, Early response protein NAK1, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen resistance, included, FLJ00280, FLJ00318, FLJ16020, FLJ16733, GFRP 1, Growth Factor Inducible Nuclear Protein NP10, Growth Factor Response Protein 1, Growth factor inducible nuclear protein N10, H 2RIIBP, HAP, HBV-activated protein, HDL cholesterol, augmented response of, to hormone replacement, included, HMR, Hbr1, Hormone Receptor, LX receptor beta, LXR a, LXR b, LXR beta, Liver X nuclear receptor beta, Liver X receptor alpha, Liver X receptor beta, MGC102720, MGC109416, MGC1831, MGC9485, MHC class I promoter binding protein, Myocardial infarction, susceptibility to, included, N10, N10 nuclear protein, NAK 1, NER I, NER1, NGFIB, NP 10, NR1B1, NR1B2, NR1B3, NR1H2_HUMAN, NR1H3_HUMAN, NR2B1, NR2B2, NR2B3, NR3A1, NR3A2, NR4A1_HUMAN, NUR77, mouse, homolog of, Nerve growth factor IB nuclear receptor variant 1, Nuclear Hormone Receptor TR3, Nuclear hormone receptor NUR/77, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear orphan receptor LXR beta, Nuclear receptor NER, Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 1 group B member 2, Nuclear receptor subfamily 1 group B member 3, Nuclear receptor subfamily 1 group H member 2, Nuclear receptor subfamily 1 group H member 3, Nuclear receptor subfamily 2 group B member 1, Nuclear receptor subfamily 2 group B member 2, Nuclear receptor subfamily 2 group B member 3, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 4 group A member 1, Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, OR-1, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000022510, OTTHUMP00000060418, Orphan nuclear receptor HMR, Orphan nuclear receptor NR4A1, Orphan nuclear receptor TR3, Orphan receptor tr3, Oxysterols receptor LXR-alpha, Oxysterols receptor LXR-beta, RAR, RAR-alpha, RAR-beta, RAR-epsilon, RAR-gamma, RARA_HUMAN, RARB_HUMAN, RARC, RARG_HUMAN, RARalpha1, RIP15, RLD 1, RNESTROR, RRB2, RXR alpha1, RXR beta, RXR gamma, RXRA_HUMAN, RXRB_HUMAN, RXRC, RXRG_HUMAN, Receptor NGFIB, Retanoic X receptor gamma, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor RXR-alpha, Retinoic acid receptor RXR-beta, Retinoic acid receptor RXR-gamma, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, Retinoic acid receptor beta, Retinoic acid receptor beta 2, Retinoic acid receptor beta 4, Retinoic acid receptor beta 5, Retinoic acid receptor beta polypeptide, Retinoic acid receptor gamma 2, Retinoic acid receptor, gamma, Retinoid X nuclear receptor alpha, Retinoid X receptor alpha, Retinoid X receptor beta, Retinoid X receptor gamma, ST-59, Steroid hormone nuclear receptor NER, Steroid receptor TR3, TR 3, TR3 orphan receptor, Testicular receptor 3, UNR, Ubiquitously-expressed nuclear receptor
Key facts
- CAS number
5300-03-8
- Purity
> 98%
- Form
Solid
- Molecular weight
300.4 Da
- Molecular formula
C20H28O2
- PubChem identifier
449171
- Nature
Synthetic
- Solubility
In water, 0.126 mg/L at 25 °C (est). In ethanol, 7.01 mg/g at 25 °C.
- Biochemical name
Alitretinoin
- Biological description
High affinity, endogenous retinoic acid receptor (RAR) agonist (IC50= 14 nM for RARα, RARβ and RARγ). Active metabolite of vitamin A. Acts as a transcription factor to regulate the growth and differentiation of normal and malignant cells and capable of inhibiting prostaglandin-endoperoxide synthase 2 expression.
- Canonical SMILES
CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
- Isomeric SMILES
CC1=C(C(CCC1)(C)C)/C=C/C(=C\C=C\C(=C\C(=O)O)\C)/C
- InChI
InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
- InChIKey
SHGAZHPCJJPHSC-ZVCIMWCZSA-N
- IUPAC name
(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions, The product can be stored for up to 12 months
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