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AB120581

A-412997 dihydrochloride, D4 agonist

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MW 382.33 g/mol, Purity >98%. Highly selective dopamine D4 receptor agonist at rat D4 and human D4.4 receptors (Ki values are 12.1 and 7.9 nM, respectively). Potent, full agonist at rat dopamine D4 receptors (EC50 = 28.4 nM). Superior selectivity profile to PD168077 (ab120568) and CP226269. No affinity for other dopamine receptors (Ki > 1 μM). Able to rapidly cross the blood-brain barrier following systemic administration.
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Chemical Structure - A-412997 dihydrochloride, D4 agonist (AB120581)
  • Chemical Structure

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Chemical Structure - A-412997 dihydrochloride, D4 agonist (AB120581)

2D chemical structure image of ab120581, A-412997 dihydrochloride, D4 agonist

Key facts

CAS number

1347744-96-0

Purity

>98%

Form

Solid

form

Molecular weight

382.33 g/mol

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biological description

Highly selective dopamine D4 receptor agonist at rat D4 and human D4.4 receptors (Ki values are 12.1 and 7.9 nM, respectively). Potent, full agonist at rat dopamine D4 receptors (EC50 = 28.4 nM). Superior selectivity profile to PD168077 (ab120568) and CP226269. No affinity for other dopamine receptors (Ki > 1 μM). Able to rapidly cross the blood-brain barrier following systemic administration.

IUPAC Name

N-(3-Methylphenyl)-2-[4-(2-pyridinyl)-1-piperidinyl]acetamide dihydrochloride

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Product protocols

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