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AB120413

A 438079, competitive P2X7 receptor antagonist

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(4 Publications)

MW 342.6 Da, Purity >98%. Potent, competitive P2X7 receptor antagonist (pIC50 = 6.5 nM). Shown to reduce pathological nociception.
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Chemical Structure - A 438079, competitive P2X7 receptor antagonist (AB120413)
  • Chemical Structure

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Chemical Structure - A 438079, competitive P2X7 receptor antagonist (AB120413)

2D chemical structure image of ab120413, A 438079, competitive P2X7 receptor antagonist

Key facts

CAS number

899431-18-6

Purity

>98%

Form

Solid

form

Molecular weight

342.6 Da

Molecular formula

C<sub>1</sub><sub>3</sub>H<sub>1</sub><sub>0</sub>Cl<sub>3</sub>N<sub>5</sub>

PubChem

11688742

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in water to 5 mM

Biochemical name

A 438079 hydrochloride

Biological description

Potent, competitive P2X7 receptor antagonist (pIC50 = 6.5 nM). Shown to reduce pathological nociception.

Canonical smiles

C1=CC(=C(C(=C1)Cl)Cl)C2=NN=NN2CC3=CN=CC=C3.Cl

InChi

InChI=1S/C13H9Cl2N5.ClH/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9;/h1-7H,8H2;1H

InChiKey

MBTJFFMIPPMRGR-UHFFFAOYSA-N

IUPAC Name

3-[[5-(2,3-dichlorophenyl)tetrazol-1-yl]methyl]pyridine;hydrochloride

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Complementary Products

Primary Antibodies

AB129002

Anti-Vinculin antibody [EPR8185] - Loading Control

20ul selling size|RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Vinculin antibody [EPR8185] - Loading Control (AB129002)

  • 5
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Biochemicals

AB120421

KN-62, CaM kinase II inhibitor. P2X7 antagonist.

Immunocytochemistry/ Immunofluorescence - KN-62, CaM kinase II inhibitor. P2X7 antagonist. (AB120421)

  • 0
  • 0
Reagents, Controls & Accessories

AB176756

Phalloidin-iFluor 555 Reagent

Immunocytochemistry/ Immunofluorescence - Phalloidin-iFluor 555 Reagent (AB176756)

  • 4
  • 3
Primary Antibodies

AB171944

Anti-QPRT antibody [EPR11941(B)]

RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-QPRT antibody [EPR11941(B)] (AB171944)

  • 0
  • 0
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cancer immunology research 10:871-884 PubMed35588154

2022

P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Kelsey M Wanhainen,Changwei Peng,Maggie H Zhou,Bruna de Gois Macedo,Stephen O'Flanagan,Tingyuan Yang,Ameeta Kelekar,Brandon J Burbach,Henrique Borges da Silva,Stephen C Jameson

International journal of molecular medicine 49: PubMed35266010

2022

Potential mechanisms of osteoprotegerin-induced damage to osteoclast adhesion structures via P2X7R-mediated MAPK signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yonggang Ma,Xueni Shi,Hongyan Zhao,Ruilong Song,Hui Zou,Jiaqiao Zhu,Zongping Liu

Toxicology letters 333:22-32 PubMed32721574

2020

P2X7R orchestrates the progression of murine hepatic fibrosis by making a feedback loop from macrophage to hepatic stellate cells.

Applications

Unspecified application

Species

Unspecified reactive species

Min Jiang,Ben-Wen Cui,Yan-Ling Wu,Yu Zhang,Yue Shang,Jian Liu,Hong-Xu Yang,Chun-Ying Qiao,Zi-Ying Zhan,Huan Ye,Quan Jin,Ji-Xing Nan,Li-Hua Lian

International journal of molecular sciences 18: PubMed29077063

2017

P2X4 Receptor-Dependent Ca Influx in Model Human Monocytes and Macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Janice A Layhadi,Samuel J Fountain
View all publications
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