MW 342.6 Da, Purity >98%. Potent, competitive P2X7 receptor antagonist (pIC50 = 6.5 nM). Shown to reduce pathological nociception.
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- Cancer immunology research 10:871-8842022P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKelsey M Wanhainen,Changwei Peng,Maggie H Zhou,Bruna de Gois Macedo,Stephen O'Flanagan,Tingyuan Yang,Ameeta Kelekar,Brandon J Burbach,Henrique Borges da Silva,Stephen C JamesonPubMed 35588154
- International journal of molecular medicine 49:2022Potential mechanisms of osteoprotegerin-induced damage to osteoclast adhesion structures via P2X7R-mediated MAPK signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYonggang Ma,Xueni Shi,Hongyan Zhao,Ruilong Song,Hui Zou,Jiaqiao Zhu,Zongping LiuPubMed 35266010
- Toxicology letters 333:22-322020P2X7R orchestrates the progression of murine hepatic fibrosis by making a feedback loop from macrophage to hepatic stellate cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMin Jiang et. al.PubMed 32721574
- International journal of molecular sciences 18:2017P2X4 Receptor-Dependent Ca Influx in Model Human Monocytes and Macrophages.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJanice A Layhadi et. al.PubMed 29077063
- Journal of neural transmission (Vienna, Austria : 117:681-72010On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDaniel Marcellino et. al.PubMed 20387084
- Neuroscience 146:1817-282007P2X7-related modulation of pathological nociception in rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesS McGaraughty et. al.PubMed 17478048
- British journal of pharmacology 151:571-92007Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states.Applications:Unspecified applicationReactive species:Unspecified reactive speciesD L Donnelly-Roberts,M F JarvisPubMed 17471177
Key facts
- CAS number
899431-18-6
- Purity
> 98%
- Form
Solid
- Molecular weight
342.6 Da
- Molecular formula
C13H10Cl3N5
- PubChem identifier
11688742
- Nature
Synthetic
Recommended products
MW 342.6 Da, Purity >98%. Potent, competitive P2X7 receptor antagonist (pIC50 = 6.5 nM). Shown to reduce pathological nociception.
Key facts
- CAS number
899431-18-6
- Purity
> 98%
- Form
Solid
- Molecular weight
342.6 Da
- Molecular formula
C13H10Cl3N5
- PubChem identifier
11688742
- Nature
Synthetic
- Solubility
Soluble in DMSO to 100 mM. Soluble in water to 5 mM.
- Biochemical name
A 438079 hydrochloride
- Biological description
Potent, competitive P2X7 receptor antagonist (pIC50 = 6.5 nM). Shown to reduce pathological nociception.
- Canonical SMILES
C1=CC(=C(C(=C1)Cl)Cl)C2=NN=NN2CC3=CN=CC=C3.Cl
- InChI
InChI=1S/C13H9Cl2N5.ClH/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9;/h1-7H,8H2;1H
- InChIKey
MBTJFFMIPPMRGR-UHFFFAOYSA-N
- IUPAC name
3-[[5-(2,3-dichlorophenyl)tetrazol-1-yl]methyl]pyridine;hydrochloride
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
Ambient
- Appropriate long-term storage conditions
Ambient
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - A 438079, competitive P2X7 receptor antagonist (ab120413)
2D chemical structure image of ab120413, A 438079, competitive P2X7 receptor antagonist
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