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MW 390.3 Da, Purity >99%. Potent, selective α1A-adrenoceptor agonist. Increases spontaneous Ca2+ transients in myocytes (EC50 = 7 nM). Shows vasoconstrictive and hypertensive effects *in vivo.*.

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Images

Chemical Structure - A 61603, alpha1A-adrenoceptor agonist (AB144571), expandable thumbnail

Publications

Key facts

CAS number

107756-30-9

Purity

> 99%

Form

Solid

Molecular weight

390.3 Da

Molecular formula

C14H20BrN3O3S

PubChem identifier

9865178

Nature

Synthetic

Alternative names

Recommended products

MW 390.3 Da, Purity >99%. Potent, selective α1A-adrenoceptor agonist. Increases spontaneous Ca2+ transients in myocytes (EC50 = 7 nM). Shows vasoconstrictive and hypertensive effects *in vivo.*.

Key facts

Purity

> 99%

PubChem identifier

9865178

Solubility

Soluble in water to 10 mM. Soluble in ethanol to 10mM. Soluble in DMSO to 100mM.

Biochemical name

A 61603 Hydrobromide

Biological description

Potent, selective α1A-adrenoceptor agonist. Increases spontaneous Ca2+ transients in myocytes (EC50 = 7 nM). Shows vasoconstrictive and hypertensive effects *in vivo.*

Canonical SMILES

CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O.Br

InChI

InChI=1S/C14H19N3O3S.BrH/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18;/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16);1H

InChIKey

LRFLWCZMTGTUEP-UHFFFAOYSA-N

IUPAC name

N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide;hydrobromide

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The ADRA2B also known as alpha-2B adrenergic receptor is a G protein-coupled receptor that interacts with catecholamines like norepinephrine and epinephrine. This receptor with a mass of around 54 kDa forms a part of the adrenergic receptor family which includes other members like the alpha-1 adrenergic receptor (ADRA1) and alpha-2A adrenergic receptor. The ADRA2B is mainly expressed in various tissues including adipose tissue the central nervous system and vascular smooth muscles playing a significant role in mediating several physiological responses.

Biological function summary

The ADRA2B receptor facilitates vasoconstriction inhibiting neurotransmitter release in the sympathetic nervous system. It does not typically form part of a large protein complex but interacts with G proteins to mediate its cellular effects. This receptor also works by modulating levels of cyclic AMP within cells thereby influencing cellular signaling and response to stress stimuli.

Pathways

The ADRA2B receptor largely contributes to the adrenergic signaling pathway which is important for the fight-or-flight response. Additionally it engages with related pathways such as the MAPK signaling pathway impacting cellular responses like proliferation and differentiation. Within these pathways it interacts with proteins like beta-adrenergic receptors coordinating with them to fine-tune cardiovascular and metabolic functions.

Associated diseases and disorders

The ADRA2B receptor has associations with conditions like hypertension and heart failure. Its role in promoting vasoconstriction links it to elevated blood pressure where it frequently interacts with proteins like angiotensin II receptors. Additionally variations in the ADRA2B gene have appeared in research concerning post-traumatic stress disorder (PTSD) potentially due to its interaction with noradrenergic systems affecting stress hormone release.

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1 product image

  • Chemical Structure - A 61603, alpha1A-adrenoceptor agonist (ab144571), expandable thumbnail

    Chemical Structure - A 61603, alpha1A-adrenoceptor agonist (ab144571)

    2D chemical structure image of ab144571, A 61603, alpha1A-adrenoceptor agonist

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Product protocols

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