A 769662, AMP-activated protein kinase activator

5

(1 Review)

|

(27 Publications)

MW 360.4 Da, Purity >99%. Potent, reversible activator of AMP-activated protein kinase (AMPK) (EC₅₀ = 0.8 μM). Directly activates native rat AMPK by mimicking the effects of AMP - it activates AMPK both allosterically and by inhibiting dephosphorylation of AMPK. Shown to inhibit Na⁺-K⁺-ATPase at higher concentrations (IC₅₀ = 57 μM). Inhibits differentiation of adipocytes.

View Alternative Names

1300015D22Rik, 5 AMP activated protein kinase alpha 1catalytic subunit, 5 AMP activated protein kinase catalytic alpha 1 chain, 5 AMP activated protein kinase subunit gamma 3, 5' AMP activated protein kinase gamma 1 subunit, 5' AMP activated protein kinase beta 2 subunit, 5' AMP activated protein kinase subunit beta 2, 5' AMP activated protein kinase subunit gamma 1, 5''-AMP-activated protein kinase subunit beta-1, 5''-AMP-activated protein kinase subunit beta-2, 5''-AMP-activated protein kinase subunit gamma-1, 5''-AMP-activated protein kinase subunit gamma-2, 5''-AMP-activated protein kinase subunit gamma-3, 5'-AMP-activated protein kinase beta-1 subunit, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase catalytic subunit alpha-2, AAKB1_HUMAN, AAKB2_HUMAN, AAKG, AAKG1_HUMAN, AAKG2_HUMAN, AAKG3_HUMAN, AAPK1_HUMAN, AAPK2_HUMAN, ACACA kinase, AI194361, AI450832, AL024255, AMP activated protein kinase beta 2 non catalytic subunit, AMP activated protein kinase noncatalytic gamma 1 subunit, AMP-ACTIVATED PROTEIN KINASE, NONCATALYTIC, BETA-1, AMP-activate kinase alpha 1 subunit, AMP-activated protein kinase beta subunit, AMP-activated protein kinase, catalytic, alpha -1, AMP-activated, noncatalytic, beta-1, AMPK, AMPK 1, AMPK alpha 1, AMPK alpha 1 chain, AMPK alpha 2 chain, AMPK beta 1 chain, AMPK beta 2, AMPK beta 2 chain, AMPK gamma 1 chain, AMPK gamma 3 chain, AMPK gamma1, AMPK gamma2, AMPK gamma3, AMPK subunit alpha-1, AMPK subunit alpha-2, AMPK subunit beta-1, AMPK subunit beta-2, AMPK subunit gamma-1, AMPK subunit gamma-2, AMPK subunit gamma-3, AMPK-BETA-1, AMPK2, AMPKG3, AMPKa1, AMPKa2, AMPKalpha2, AMPKb, AMPKg, AU021155, Acetyl-CoA carboxylase kinase, C130083N04Rik, CMH6, E430008F22, EC 2.7.11.1, H91620p, HAMPKb, HMG CoA reductase kinase, HMGCR kinase, Hydroxymethylglutaryl-CoA reductase kinase, MGC17785, MGC33776, MGC57364, MGC61468, MGC8666, OTTHUMP00000161795, OTTHUMP00000161796, PRKAA, PRKAA 1, PRKAA2, PRKAB 2, PRKAB1, PRKAG 1, PRKAG3, Prkag2, Protein kinase AMP activated alpha 1 catalytic subunit, Protein kinase AMP activated alpha 2 catalytic subunit, Protein kinase AMP activated beta 2 non catalytic subunit, Protein kinase AMP activated catalytic subunit alpha 2, Protein kinase AMP activated gamma 1 non catalytic subunit, Protein kinase AMP activated gamma 2 non catalytic subunit, Protein kinase AMP activated gamma 3 non catalytic subunit, Protein kinase AMP activated non catalytic subunit beta 1, SNF1-like protein AMPK, SNF1A, Tau-protein kinase PRKAA1, WPWS, cb116, hormone sensitive lipase kinase, im:7154392, kinase AMPK alpha1, protein kinase, AMP-activated, beta 1 non-catalytic subunit, protein kinase, AMP-activated, noncatalytic gamma-1, protein kinase, AMP-activated, noncatalytic, beta-1, wu:fa94c10