A 803467, NaV1.8 channel blocker

Key facts

CAS number

944261-79-4

Purity

>98%

Form

Solid

form

Molecular weight

357.8 Da

Molecular formula

C₁₉H₁₆ClNO₄

PubChem

16038374

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM and in ethanol to 25 mM

Biochemical name

5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide

Biological description

Selective blocker of Na_V1.8 channels (IC₅₀ = 8 nM for human Na_V1.8 ). Shows greater than 100-fold selectivity over human Na_V1.2, Na_V1.3, Na_V1.5, and Na_V1.7 (IC₅₀ values =1 μM). Shows no significant activity against TRPV1, P2X_2/3, Ca_V2.2 and KCNQ2/3 channels. Antinociceptive.

Canonical smiles

COC1=CC(=CC(=C1)NC(=O)C2=CC=C(O2)C3=CC=C(C=C3)Cl)OC

InChi

InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)

InChiKey

VHKBTPQDHDSBSP-UHFFFAOYSA-N

IUPAC Name

5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide