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MW 421.5 Da, Purity >98%. Potent, selective TGF-β type I receptor ALK5, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC50 values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). TGF-β1 inhibitor. Inhibits TGF-β1-dependent α-SMA and collagen type I induction. Active in vivo and in vitro.

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Images

Chemical Structure - A 83-01, ALK4, 5 and 7 kinase inhibitor (AB142092), expandable thumbnail

Key facts

CAS number
909910-43-6
Purity
> 98%
Form
Solid
Molecular weight
421.5 Da
Molecular formula
C25H19N5S
PubChem identifier
16218924
Nature
Synthetic

Target data

Alternative names

ARVD, ARVD1, BSC-1 cell growth inhibitor, CED, Cartilage-inducing factor, Cellular Yes 1 protein, Cetermin, DPD1, Differentiation inhibiting factor, FLJ16571, G-TSF, Glioblastoma-derived T-cell suppressor factor, HsT441, LAP, LDS5, Latency-associated peptide, MGC105479, MGC116892, MGC118722, MGF, Milk growth factor, Polyergin, Prepro transforming growth factor beta 1, Proto oncogene tyrosine protein kinase YES, Proto-oncogene c-Yes, RNHF, TGF beta, TGF-beta 1 protein, TGF-beta-1, TGF-beta-2, TGF-beta-3, TGF-beta-5, TGFB, TGFB1_HUMAN, TGFB2_HUMAN, TGFB3_HUMAN, Transforming Growth Factor b1, Transforming Growth Factor beta-1, Transforming Growth Factor-鑴1, Transforming growth factor beta 1a, Transforming growth factor beta 2, Transforming growth factor beta-3, Tyrosine-protein kinase Yes, Viral oncogene yes 1 homolog 1, YES proto oncogene 1, Src family tyrosine kinase, YES1 proto oncogene, Src family tyrosine kinase, YES_HUMAN, Yamaguchi sarcoma oncogene, Yes 1, c Yes, p61-Yes, prepro-transforming growth factor beta-3, v yes 1 Yamaguchi sarcoma viral oncogene homolog 1

Recommended products

MW 421.5 Da, Purity >98%. Potent, selective TGF-β type I receptor ALK5, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC50 values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). TGF-β1 inhibitor. Inhibits TGF-β1-dependent α-SMA and collagen type I induction. Active in vivo and in vitro.

Key facts

Purity
> 98%
PubChem identifier
16218924
Biochemical name
3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide
Biological description

Potent, selective TGF-β type I receptor ALK5, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC50 values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). TGF-β1 inhibitor. Inhibits TGF-β1-dependent α-SMA and collagen type I induction. Active in vivo and in vitro.

Canonical SMILES
CC1=NC(=CC=C1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5
InChI
InChI=1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)
InChIKey
HIJMSZGHKQPPJS-UHFFFAOYSA-N
IUPAC name
3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
Reconstitution
Reconstitute in DMSO

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 1725 A 83-01. 1725-1 is the same size as the 1 mg size of ab142092.


Handling


Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Refer to SDS for further information.

Product promise

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Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Chemical Structure - A 83-01, ALK4, 5 and 7 kinase inhibitor (ab142092), expandable thumbnail

    Chemical Structure - A 83-01, ALK4, 5 and 7 kinase inhibitor (ab142092)

    2D chemical structure image of ab142092, A 83-01, ALK4, 5 and 7 kinase inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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