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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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MW 421.5 Da, Purity >98%. Potent, selective TGF-β type I receptor ALK5, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC50 values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). TGF-β1 inhibitor. Inhibits TGF-β1-dependent α-SMA and collagen type I induction. Active in vivo and in vitro.
Also available as a solid (ab142092).
909910-43-6
> 98%
Solid
421.5 Da
C25H19N5S
16218924
Synthetic
ARVD, ARVD1, BSC-1 cell growth inhibitor, CED, Cartilage-inducing factor, Cellular Yes 1 protein, Cetermin, DPD1, Differentiation inhibiting factor, FLJ16571, G-TSF, Glioblastoma-derived T-cell suppressor factor, HsT441, LAP, LDS5, Latency-associated peptide, MGC105479, MGC116892, MGC118722, MGF, Milk growth factor, Polyergin, Prepro transforming growth factor beta 1, Proto oncogene tyrosine protein kinase YES, Proto-oncogene c-Yes, RNHF, TGF beta, TGF-beta 1 protein, TGF-beta-1, TGF-beta-2, TGF-beta-3, TGF-beta-5, TGFB, TGFB1_HUMAN, TGFB2_HUMAN, TGFB3_HUMAN, Transforming Growth Factor b1, Transforming Growth Factor beta-1, Transforming Growth Factor-鑴1, Transforming growth factor beta 1a, Transforming growth factor beta 2, Transforming growth factor beta-3, Tyrosine-protein kinase Yes, Viral oncogene yes 1 homolog 1, YES proto oncogene 1, Src family tyrosine kinase, YES1 proto oncogene, Src family tyrosine kinase, YES_HUMAN, Yamaguchi sarcoma oncogene, Yes 1, c Yes, p61-Yes, prepro-transforming growth factor beta-3, v yes 1 Yamaguchi sarcoma viral oncogene homolog 1
MW 421.5 Da, Purity >98%. Potent, selective TGF-β type I receptor ALK5, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC50 values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). TGF-β1 inhibitor. Inhibits TGF-β1-dependent α-SMA and collagen type I induction. Active in vivo and in vitro.
Also available as a solid (ab142092).
ARVD, ARVD1, BSC-1 cell growth inhibitor, CED, Cartilage-inducing factor, Cellular Yes 1 protein, Cetermin, DPD1, Differentiation inhibiting factor, FLJ16571, G-TSF, Glioblastoma-derived T-cell suppressor factor, HsT441, LAP, LDS5, Latency-associated peptide, MGC105479, MGC116892, MGC118722, MGF, Milk growth factor, Polyergin, Prepro transforming growth factor beta 1, Proto oncogene tyrosine protein kinase YES, Proto-oncogene c-Yes, RNHF, TGF beta, TGF-beta 1 protein, TGF-beta-1, TGF-beta-2, TGF-beta-3, TGF-beta-5, TGFB, TGFB1_HUMAN, TGFB2_HUMAN, TGFB3_HUMAN, Transforming Growth Factor b1, Transforming Growth Factor beta-1, Transforming Growth Factor-鑴1, Transforming growth factor beta 1a, Transforming growth factor beta 2, Transforming growth factor beta-3, Tyrosine-protein kinase Yes, Viral oncogene yes 1 homolog 1, YES proto oncogene 1, Src family tyrosine kinase, YES1 proto oncogene, Src family tyrosine kinase, YES_HUMAN, Yamaguchi sarcoma oncogene, Yes 1, c Yes, p61-Yes, prepro-transforming growth factor beta-3, v yes 1 Yamaguchi sarcoma viral oncogene homolog 1
909910-43-6
> 98%
Solid
421.5 Da
C25H19N5S
16218924
Synthetic
3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide
Potent, selective TGF-β type I receptor ALK5, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC50 values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). TGF-β1 inhibitor. Inhibits TGF-β1-dependent α-SMA and collagen type I induction. Active in vivo and in vitro.
Also available as a solid (ab142092).
CC1=NC(=CC=C1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5
InChI=1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)
HIJMSZGHKQPPJS-UHFFFAOYSA-N
3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
DMSO
Ambient - Can Ship with Ice
-20°C
Store under desiccating conditions, The product can be stored for up to 12 months
This product is manufactured by BioVision, an Abcam company and was previously called 1725 A 83-01. 1725-1 is the same size as the 1 mg size of ab142092.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2D chemical structure image of ab142092, A 83-01, ALK4, 5 and 7 kinase inhibitor
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com