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AB142092

A 83-01, ALK4, 5 and 7 kinase inhibitor

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MW 421.5 Da, Purity >98%. Potent, selective TGF-β type I receptor ALK5, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC50 values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). TGF-β1 inhibitor. Inhibits TGF-β1-dependent α-SMA and collagen type I induction. Active in vivo and in vitro.
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Chemical Structure - A 83-01, ALK4, 5 and 7 kinase inhibitor (AB142092)
  • Chemical Structure

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Chemical Structure - A 83-01, ALK4, 5 and 7 kinase inhibitor (AB142092)

2D chemical structure image of ab142092, A 83-01, ALK4, 5 and 7 kinase inhibitor

Key facts

CAS number

909910-43-6

Purity

>98%

Form

Solid

form

Molecular weight

421.5 Da

Molecular formula

C<sub>2</sub><sub>5</sub>H<sub>1</sub><sub>9</sub>N<sub>5</sub>S

PubChem

16218924

Nature

Synthetic

Biochemical name

3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide

Biological description

Potent, selective TGF-β type I receptor ALK5, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC50 values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). TGF-β1 inhibitor. Inhibits TGF-β1-dependent α-SMA and collagen type I induction. Active in vivo and in vitro.

Canonical smiles

CC1=NC(=CC=C1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5

InChi

InChI=1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)

InChiKey

HIJMSZGHKQPPJS-UHFFFAOYSA-N

IUPAC Name

3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide

Reconstitution

Reconstitute in DMSO

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1725 A 83-01. 1725-1 is the same size as the 1 mg size of ab142092.

Handling

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Refer to SDS for further information.

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Product promise

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