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MW 523.6 Da, Purity >98%. A mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria.

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Images

Chemical Structure - A23187 (Calcimycin), Ca2+ ionophore (AB120287), expandable thumbnail

Publications

Key facts

CAS number
52665-69-7
Purity
> 98%
Form
Solid
Source
Steptomyces chartreusensis
Molecular weight
523.6 Da
Molecular formula
C29H37N3O6
PubChem identifier
11957499
Nature
Native

Target data

Alternative names

ASRT2, BAP1_HUMAN, BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), BRCA1-associated protein 1, Cerebral protein 13, Cerebral protein 6, DKFZp686N04275, FLJ35406, FLJ37180, G protein coupled receptor 154, G protein coupled receptor PGR14, G protein coupled receptor for asthma susceptibility, GPR 154, GPRA, HUCEP 13, Hucep 6, KIAA0272, MVTR, NPSR, Neuropeptide S receptor, Neuropeptide S receptor 1, PGR 14, TPDS, UCHL2, Ubiquitin carboxy terminal hydrolase, Ubiquitin carboxyl-terminal hydrolase BAP1, VRR 1, Vasopressin receptor related receptor 1, nps receptor

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MW 523.6 Da, Purity >98%. A mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria.

Key facts

Purity
> 98%
Source
Steptomyces chartreusensis
PubChem identifier
11957499
Solubility

Soluble in DMSO to 100 mM (with heating).

Biochemical name
Calcimycin
Biological description

A mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria.

Canonical SMILES
CC1CCC2(C(CC(C(O2)C(C)C(=O)C3=CC=CN3)C)C)OC1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC
Isomeric SMILES
C[C@@H]1CC[C@]2([C@@H](C[C@H]([C@H](O2)[C@H](C)C(=O)C3=CC=CN3)C)C)O[C@@H]1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC
InChI
InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1
InChIKey
HIYAVKIYRIFSCZ-CYEMHPAKSA-N
IUPAC name
5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - A23187 (Calcimycin), Ca2+ ionophore (ab120287), expandable thumbnail

    Chemical Structure - A23187 (Calcimycin), Ca2+ ionophore (ab120287)

    2D chemical structure image of ab120287, A23187 (Calcimycin), Ca2+ ionophore

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Product protocols

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