MW 371.4 Da, Purity >98%. Potent, selective and cell-permeable VEGFR inhibitor (IC50 values are 130, 23 and 18 nM for VEGFR1, 2, and 3 respectively). Inhibits VEGF-induced angiogenesis in vivo. Suppresses hypoxia-induced HIF-1α expression without affecting Akt phosphorylation in vitro..
View Alternative Names
ABL, ABL proto oncogene 1 non receptor tyrosine kinase, ABL1_HUMAN, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine protein kinase 1, Avian erythroblastic leukemia viral (v erb b) oncogene homolog, Bcr/c abl oncogene protein, C-FMS, C-kit ligand, CD 115, CD 140B, CD117, CD140A, CD140a antigen, CD140b antigen, CD309, CD309 antigen, CSFR, Cell growth inhibiting protein 40, Cell proliferation inducing protein 61, Chy, EC 2.7.10.1, EGFR_HUMAN, ERBB, ERBB1, Epidermal growth factor receptor, Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog), Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian), Errp, FIM 2, FLK-1, FLK1, mouse, homolog of, FLT, FLT41, FMS, FRT, Fetal liver kinase 1, Flt-1, Fms related tyrosine kinase 1, Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor, Fms related tyrosine kinase 4, Fms-like tyrosine kinase 1, Fms-like tyrosine kinase 4, HER1, JTK7, KIT ligand, KIT oncogene, KIT proto oncogene receptor tyrosine kinase, KIT_HUMAN, KRD1, Kdr, Kinase insert domain receptor, Kinase insert domain receptor (a type III receptor tyrosine kinase), LMPH1A, Ly73, MGF, Mast cell growth factor receptor, Mast/stem cell growth factor receptor Kit, NISBD2, Oncogen ERBB, P150, PBT, PCL, PDGF Receptor alpha + beta, PDGF-R-alpha, PDGF-R-beta, PDGFR 2, PDGFRA, PDGFRB, PIG61, Piebald trait protein, Platelet derived growth factor receptor alpha, Platelet derived growth factor receptor beta, Protein-tyrosine kinase receptor flk-1, Proto oncogene tyrosine protein kinase ABL1, Proto oncogene tyrosine protein kinase Kit, Proto-oncogene c-Abl, Proto-oncogene c-ErbB-1, Proto-oncogene c-Kit, Receptor tyrosine-protein kinase ErbB-1, SA7, SCF Receptor, SCFR, Soluble VEGF receptor 1 14, Soluble VEGFR1 variant 2, Soluble VEGFR1 variant 21, Species antigen 7, Steel Factor Receptor, Stem cell factor receptor, Tyrosine kinase growth factor receptor, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase Kit, Tyrosine-protein kinase receptor FLT, Tyrosine-protein kinase receptor FLT4, Urogastrone, VEGFR, VEGFR-1, VEGFR-2, VEGFR-3, VGFR1_HUMAN, VGFR2_HUMAN, Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 3, Vascular endothelial growth factor vascular permeability factor receptor, Vascular permeability factor receptor, Vascular permeability factor receptor 1, Wa5, bcr/abl, c ABL, c abl oncogene 1 non receptor tyrosine kinase, c abl oncogene 1 receptor tyrosine kinase, c-Kit, erb-b2 receptor tyrosine kinase 1, mENA, p145 c-kit, soluble KIT variant 1, soluble VEGFR2, v abl, v abl Abelson murine leukemia viral oncogene homolog 1, v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein, v-erb-b Avian erythroblastic leukemia viral oncogen homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, wa2
- Chemical Structure
Lab
Chemical Structure - AAL 993, VEGFR inhibitor (AB141590)
2D chemical structure image of ab141590, AAL 993, VEGFR inhibitor
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These receptors participate in critical processes such as angiogenesis hematopoiesis and cell proliferation. They often exist as part of receptor-ligand complexes that activate signaling cascades upon ligand binding. VEGF Receptors 1 and 2 are important for blood vessel formation and repair. c-Kit and EGFR impact processes like stem cell maintenance and epithelial cell growth. ABL1 often found in the cytoplasm participates in cellular response to external stimuli. PDGFRs influence connective tissue development contributing to organized cell growth in various tissues.
Pathways
These receptor tyrosine kinases integrate into several key ones including the PI3K/AKT and MAPK/ERK pathways. VEGF Receptor 2 through its activation collaborates with proteins like PI3K and AKT to promote vascular growth and maintenance. c-Kit influences the MAPK/ERK pathway important for cell differentiation through its interaction with proteins such as RAF and MEK. EGFR when activated also engages the MAPK/ERK pathway facilitating epidermal regeneration. ABL1 often interacts within cell cycle control pathways and PDGFRs link to both PI3K/AKT and MAPK/ERK pathways supporting cellular responses to mechanical stresses.
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